Delineation of human plasma cell subsets and their bone marrow niche

人类浆细胞亚群及其骨髓生态位的描述

• 批准号: 168806284
• 负责人: Professor Dr. Thomas Dörner
• 金额: --
• 依托单位: Deutsches Rheuma-Forschungszentrum Berlin (DRFZ)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/168806284?language=en
• 关键词: Delineation; human; plasma; cell; subsets

An important part of humoral memory is provided by plasma cells with apparently distinct half-life times but residing in the bone marrow. Together with other groups we could identify a diversity of plasma cells and plasmablasts in the peripheral blood, including antigen-specific ones. More recently, distinct subsets of plasma cells were identified in the bone marrow of humans. Here we want to explore if these plasma cell subsets require certain soluble and insoluble survival factors with a main focus on a potential unique interaction with human bone marrow cells. In particular, the project will describe in detail their distinct phenotypes, molecular and functional characteristics and ultimately studying the specificities of anatomic sites of certain plasma cell subsets. Better understanding of the hypothetical bone marrow niches will permit innovative therapeutic approaches influencing immune memory formation and its maintenance which may have a wide range of clinical application, such immune prophylaxis and therapy.

体液记忆的一个重要部分由浆细胞提供，浆细胞具有明显不同的半衰期，但驻留在骨髓中。与其他小组一起，我们可以在外周血中鉴定出不同的浆细胞和浆母细胞，包括抗原特异性的。最近，在人类骨髓中发现了不同的浆细胞亚群。在这里，我们想要探索这些浆细胞亚群是否需要某些可溶和不可溶的生存因子，主要集中在与人骨髓细胞潜在的独特相互作用上。特别是，该项目将详细描述它们不同的表型、分子和功能特征，并最终研究某些浆细胞亚群的解剖位置的特殊性。更好地理解假说的骨髓生态位将为影响免疫记忆的形成和维持的创新治疗方法提供可能，这可能在免疫预防和治疗等临床应用中具有广泛的应用。