CAREER: Peptide Structure in Condensed Phases by Solid-State NMR

职业：通过固态 NMR 分析凝聚相中的肽结构

• 批准号: 0449629
• 负责人: Manish Mehta
• 金额: $ 50.77万
• 依托单位: Oberlin College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-15 至 2011-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0449629&HistoricalAwards=false
• 关键词: CAREER; Peptide; Structure; Condensed; Phases

In this project, funded by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. Manish A. Mehta of Oberlin College and his undergraduate research students will investigate the secondary structure of small model peptides as a function of salvation with solid state nuclear magnetic resonance (NMR) methods coupled with x-ray diffraction measurements and ab initio quantum chemical calculations on Oberlin's new 64-node Beowulf cluster. The stated goal of the research is to develop techniques and methods that will be useful for determining peptide structure in a variety of research areas.Besides the potential broader impact of the proposed research on other scientific areas, Prof. Mehta will provide his undergraduate research students with significant hands-on experience with Oberlin's high-field NMR spectrometer. Besides participating in undergraduate research, Prof. Mehta is developing research collaborations with a local community college, and he is establishing a new outreach program with local high schools, centered around the theme of NMR.

在这个项目中，由化学部实验性物理化学计划资助，Oberlin College的Manish A. Mehta教授及其本科研究的学生将研究小型肽的二级结构，这是通过固体核磁共振（NMR）与X射线衍射测量和Ab ab abrio量子量相关的固体核磁共振（NMR）的次要结构。 该研究的既定目标是开发技术和方法，这些技术和方法将有助于确定各种研究领域的肽结构。Besides拟议研究对其他科学领域的潜在更广泛的影响，MEHTA教授将为他的本科生研究学生提供与Oberlin的高档NMR NMR NMR光谱仪具有丰富的实践经验。 除了参加本科研究外，Mehta教授还正在与当地社区学院开发研究合作，他正在与当地高中建立新的外展计划，围绕NMR的主题。