CAREER: Peptide Structure in Condensed Phases by Solid-State NMR

职业：通过固态 NMR 分析凝聚相中的肽结构

• 批准号: 0449629
• 负责人: Manish Mehta
• 金额: $ 50.77万
• 依托单位: Oberlin College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-15 至 2011-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0449629&HistoricalAwards=false
• 关键词: CAREER; Peptide; Structure; Condensed; Phases

In this project, funded by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. Manish A. Mehta of Oberlin College and his undergraduate research students will investigate the secondary structure of small model peptides as a function of salvation with solid state nuclear magnetic resonance (NMR) methods coupled with x-ray diffraction measurements and ab initio quantum chemical calculations on Oberlin's new 64-node Beowulf cluster. The stated goal of the research is to develop techniques and methods that will be useful for determining peptide structure in a variety of research areas.Besides the potential broader impact of the proposed research on other scientific areas, Prof. Mehta will provide his undergraduate research students with significant hands-on experience with Oberlin's high-field NMR spectrometer. Besides participating in undergraduate research, Prof. Mehta is developing research collaborations with a local community college, and he is establishing a new outreach program with local high schools, centered around the theme of NMR.

本课题由化学系实验物理化学项目资助，Manish A.奥伯林学院的Mehta和他的本科研究生将利用固态核磁共振（NMR）方法，结合X射线衍射测量和从头算量子化学计算，对奥伯林新的64节点Beowulf簇研究小模型肽的二级结构作为拯救的函数。 该研究的既定目标是开发技术和方法，将有助于确定肽结构的各种研究领域。除了拟议的研究对其他科学领域的潜在更广泛的影响，梅塔教授将为他的本科研究生提供重要的实践经验与奥伯林的高场NMR光谱仪。 除了参与本科研究外，梅塔教授还与当地社区学院开展研究合作，并与当地高中建立一个以核磁共振为主题的新外展项目。