Environmental Variability and Evolution of Virus Specialists and Generalists

环境变化以及病毒专家和通才的进化

基本信息

  • 批准号:
    0452163
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-03-01 至 2010-02-28
  • 项目状态:
    已结题

项目摘要

Whereas some viruses can easily shift to infect new host populations, other viruses remain confined to their original host. This research examines the environmental factors which cause viruses to be specialists that infect few hosts or generalists that attack a variety of hosts. This goal is accomplished using experimental evolution of Vesicular Stomatitis Virus in laboratory culture. The first major objective is to see if different patterns of host availability affect whether specialist or generalist viruses will evolve, and can be used to predict which viruses are more likely to shift to new hosts in the future. Second is to identify the changes to the virus genome that are associated with evolved host shifts. Third is to determine whether populations of specialist and generalist viruses differ in the rate at which they evolve. Methods include techniques from a variety of disciplines, including molecular biology, population genetics, genomics and evolutionary theory.The project results can be applied to several systems because viruses are important disease agents in wild and domesticated populations of animals and plants. The project virus resembles many vector-borne human viruses (such as West Nile Fever Virus); thus, the project should help elucidate environmental factors promoting viral host shifts into human populations.
虽然有些病毒可以很容易地转移到感染新的宿主种群,但其他病毒仍然局限于它们的原始宿主。这项研究探讨了环境因素,使病毒成为专家,感染少数主机或多面手,攻击各种主机。这一目标是通过在实验室培养水泡性口炎病毒的实验进化来实现的。第一个主要目标是观察宿主可用性的不同模式是否会影响专业病毒或通用病毒的进化,并可用于预测哪些病毒更有可能在未来转移到新的宿主。第二是确定病毒基因组的变化与进化的宿主转移有关。第三是确定专家和通用病毒的种群在进化速度上是否不同。研究方法包括分子生物学、群体遗传学、基因组学和进化理论等多个学科的技术,由于病毒是野生和驯养动植物群体中的重要致病因子,项目结果可应用于多个系统。该项目病毒类似于许多媒介传播的人类病毒(如西尼罗河热病毒);因此,该项目应有助于阐明促进病毒宿主转移到人群中的环境因素。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Paul Turner其他文献

Journal Pre-proof Burkholderia pseudomallei multi-centre study to establish EUCAST MIC and zone diameter distributions and epidemiological cut-off (ECOFF) values
期刊预证明类鼻疽伯克霍尔德氏菌多中心研究,旨在建立 EUCAST MIC 和区域直径分布以及流行病学截止值 (ECOFF)
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Onur Karatuna;David A. B. Dance;E. Matuschek;J. Åhman;Paul Turner;Jill;Hopkins;Premjit Amornchai;V. Wuthiekanun;Tomas;Rob Baird;Jann;Hennessy;Robert E Norton;Mark Armstrong;S. Zange;Lothar Zoeller;Tara Wahab;D. Jacob;Roland Grunow;Gunnar Kahlmeter
  • 通讯作者:
    Gunnar Kahlmeter
Molecular Epidemiology of Group A Streptococcus Infections in Cambodian Children, 2007–2012
2007-2012 年柬埔寨儿童 A 组链球菌感染的分子流行病学
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Paul Turner;P. Ngeth;Claudia Turner;Sena Sao;Nicholas P. J. Day;C. Baker;Andrew C. Steer;P. Smeesters
  • 通讯作者:
    P. Smeesters
Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine
异喹啉羟基化表型对美西律药代动力学的影响
Water management in sport
  • DOI:
    10.1016/j.smr.2013.08.002
  • 发表时间:
    2014-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Pamm Phillips;Paul Turner
  • 通讯作者:
    Paul Turner
Routine versus selective contrast imaging to identify the need for early re-intervention following laparoscopic fundoplication: A retrospective cohort study
  • DOI:
    10.1016/j.ijsu.2015.06.052
  • 发表时间:
    2015-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Khalid Shahzad;Ashok Menon;Paul Turner;Jeremy Ward;Kishore Pursnani;Bilal Alkhaffaf
  • 通讯作者:
    Bilal Alkhaffaf

Paul Turner的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Paul Turner', 18)}}的其他基金

MICA: Identifying risks for severe life-threatening allergic reactions to foods (IRIS-Allergy)
MICA:识别严重危及生命的食物过敏反应的风险(IRIS-Allergy)
  • 批准号:
    MR/W018616/1
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Exploring mechanisms to optimise the duration of oral immunotherapy for peanut allergy
探索优化花生过敏口服免疫治疗持续时间的机制
  • 批准号:
    MR/W025639/1
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Improved diagnostics in food allergy (ID-in-FA) Study
改进食物过敏诊断 (ID-in-FA) 研究
  • 批准号:
    MR/S036954/1
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Grant
2013 Microbial Population Biology GRC/GRS
2013年微生物种群生物学GRC/GRS
  • 批准号:
    1314149
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Mechanisms underlying the physiological and cellular response to food allergen challenge in human subjects with peanut allergy
花生过敏人类受试者对食物过敏原挑战的生理和细胞反应的机制
  • 批准号:
    MR/K010468/1
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Fellowship
DISSERTATION RESEARCH: The proximate basis of behavioral plasticity in the butterfly Bicyclus anynana
论文研究:蝴蝶 Bicyclus annana 行为可塑性的直接基础
  • 批准号:
    1110523
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Effects of host-use traits on RNA virus evolvability
宿主使用特征对 RNA 病毒进化能力的影响
  • 批准号:
    1051093
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
DISSERTATION RESEARCH: Pre-mating experience influences female mate preference in the butterfly Bicyclus anynana
论文研究:交配前经历影响蝴蝶 Bicyclus annana 的雌性交配偏好
  • 批准号:
    1110382
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
DISSERTATION RESEARCH: Life History Coevolution Between an Aging Bacterium and its Bacteriophage
论文研究:衰老细菌与其噬菌体之间的生命史共同进化
  • 批准号:
    0608398
  • 财政年份:
    2006
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
DISSERTATION RESEARCH: Evolution of Generalism and Specialism in the RNA phage Phi6
论文研究:RNA 噬菌体 Phi6 的通用性和专业性的进化
  • 批准号:
    0408000
  • 财政年份:
    2004
  • 资助金额:
    --
  • 项目类别:
    Standard Grant

相似国自然基金

Accretion variability and its consequences: from protostars to planet-forming disks
  • 批准号:
    12173003
  • 批准年份:
    2021
  • 资助金额:
    60 万元
  • 项目类别:
    面上项目

相似海外基金

RCN: The Herbivory Variability Network: Expanding beyond the mean to embrace higher moments in the ecology and evolution of species interactions
RCN:草食变异网络:超越平均值,拥抱生态学和物种相互作用进化中的更高时刻
  • 批准号:
    2409605
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
RCN: The Herbivory Variability Network: Expanding beyond the mean to embrace higher moments in the ecology and evolution of species interactions
RCN:草食变异网络:超越平均值,拥抱生态学和物种相互作用进化中的更高时刻
  • 批准号:
    2203582
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Hydroclimate Variability and the Evolution of Socioecological Complexity in Dryland Farming Communities
旱地农业社区的水文气候变化和社会生态复杂性的演变
  • 批准号:
    2115151
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Combining experimental embryology and geometric morphometrics to uncover the evolution of vertebral variability in Lake Malawi cichlids
结合实验胚胎学和几何形态测量学来揭示马拉维湖慈鲷脊椎变异的进化
  • 批准号:
    2445747
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
    Studentship
RAPID: Collaborative Research: Evolution and variability of modern human sleep patterns
RAPID:协作研究:现代人类睡眠模式的演变和变异
  • 批准号:
    1743364
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
RAPID: Collaborative Research: Evolution and variability of modern human sleep patterns
RAPID:协作研究:现代人类睡眠模式的演变和变异
  • 批准号:
    1743395
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Impact of Western Pacific Warm Pool variability on regional and global climate evolution during the late Miocene and early Pliocene
中新世晚期和上新世早期西太平洋暖池变率对区域和全球气候演变的影响
  • 批准号:
    387857866
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
    Infrastructure Priority Programmes
Immunity to novel T/F SHIVs: variability in the co-evolution of virus and host immunity
对新型 T/F SHIV 的免疫:病毒和宿主免疫共同进化的变异性
  • 批准号:
    10200002
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
Evolution of insect learning styles and behavioural syndromes in response to environmental variability and reliability of information.
昆虫学习风格和行为综合症响应环境变化和信息可靠性的演变。
  • 批准号:
    386527848
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Immunity to novel T/F SHIVs: variability in the co-evolution of virus and host immunity
对新型 T/F SHIV 的免疫:病毒和宿主免疫共同进化的变异性
  • 批准号:
    9976437
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了