DISSERTATION RESEARCH: Life History Coevolution Between an Aging Bacterium and its Bacteriophage
论文研究:衰老细菌与其噬菌体之间的生命史共同进化
基本信息
- 批准号:0608398
- 负责人:
- 金额:$ 0.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-06-01 至 2008-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Many parasites establish infections through two different pathways: vertical transmission to offspring of infected hosts, and horizontal transmission to uninfected hosts. This study examines a key, unexplored question regarding parasite behavior: how does host aging influence parasite transmission? A mathematical model of host-parasite dynamics predicts increased horizontal transmission as host age increases and reproduction declines. Preliminary results from a model bacterial system confirm this expectation. Further experiments using this bacterial system will examine the behavior of parasites upon introduction to hosts with varying aging patterns. Initial parasite behavior in these new hosts will identify any general ability of parasites to detect and respond to differences in host aging. Laboratory evolution experiments will subsequently explore parasite behaviors that require specialization to a particular host. Taken together, these efforts explore the role of host aging in shaping parasite transmission behavior from both theoretical and empirical perspectives.This study develops both a mathematical modeling framework and an experimental system for exploring the effects of host aging on parasite behavior. This research thus provides theoretical and experimental tools for future research on vertically transmitted parasites. This class of parasites includes agents of human disease such as AIDS and cancer, as well as infectious agents of crops and livestock. Understanding the basic behavior of such parasites will therefore assist in effectively managing organisms that detrimentally impact human health and the economy.
许多寄生虫通过两种不同的途径建立感染:垂直传播到受感染宿主的后代,以及水平传播到未受感染的宿主。这项研究探讨了一个关键的,未探索的问题,关于寄生虫的行为:如何主机老化影响寄生虫传播?宿主-寄生虫动力学的数学模型预测随着宿主年龄的增加和繁殖能力的下降,水平传播会增加。来自模型细菌系统的初步结果证实了这一预期。使用这种细菌系统的进一步实验将检查寄生虫在引入具有不同老化模式的宿主后的行为。这些新宿主的初始寄生虫行为将识别寄生虫检测和响应宿主老化差异的任何一般能力。实验室进化实验随后将探索寄生虫的行为,需要专门化到一个特定的主机。这些研究从理论和实证两个角度探讨了宿主衰老对寄生虫传播行为的影响,建立了宿主衰老对寄生虫传播行为影响的数学模型和实验系统。本研究为今后垂直传播寄生虫的研究提供了理论和实验工具。这类寄生虫包括艾滋病和癌症等人类疾病的病原体,以及农作物和牲畜的传染性病原体。因此,了解这些寄生虫的基本行为将有助于有效地管理对人类健康和经济产生负面影响的生物体。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Paul Turner其他文献
Journal Pre-proof Burkholderia pseudomallei multi-centre study to establish EUCAST MIC and zone diameter distributions and epidemiological cut-off (ECOFF) values
期刊预证明类鼻疽伯克霍尔德氏菌多中心研究,旨在建立 EUCAST MIC 和区域直径分布以及流行病学截止值 (ECOFF)
- DOI:
- 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
Onur Karatuna;David A. B. Dance;E. Matuschek;J. Åhman;Paul Turner;Jill;Hopkins;Premjit Amornchai;V. Wuthiekanun;Tomas;Rob Baird;Jann;Hennessy;Robert E Norton;Mark Armstrong;S. Zange;Lothar Zoeller;Tara Wahab;D. Jacob;Roland Grunow;Gunnar Kahlmeter - 通讯作者:
Gunnar Kahlmeter
Influence of debrisoquine hydroxylation phenotype on the pharmacokinetics of mexiletine
异喹啉羟基化表型对美西律药代动力学的影响
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:2.9
- 作者:
P. Lledo;S. Abrams;Atholl Johnston;Mahesh Patel;R. Pearson;Paul Turner - 通讯作者:
Paul Turner
Molecular Epidemiology of Group A Streptococcus Infections in Cambodian Children, 2007–2012
2007-2012 年柬埔寨儿童 A 组链球菌感染的分子流行病学
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:0
- 作者:
Paul Turner;P. Ngeth;Claudia Turner;Sena Sao;Nicholas P. J. Day;C. Baker;Andrew C. Steer;P. Smeesters - 通讯作者:
P. Smeesters
Routine versus selective contrast imaging to identify the need for early re-intervention following laparoscopic fundoplication: A retrospective cohort study
- DOI:
10.1016/j.ijsu.2015.06.052 - 发表时间:
2015-08-01 - 期刊:
- 影响因子:
- 作者:
Khalid Shahzad;Ashok Menon;Paul Turner;Jeremy Ward;Kishore Pursnani;Bilal Alkhaffaf - 通讯作者:
Bilal Alkhaffaf
Water management in sport
- DOI:
10.1016/j.smr.2013.08.002 - 发表时间:
2014-08-01 - 期刊:
- 影响因子:
- 作者:
Pamm Phillips;Paul Turner - 通讯作者:
Paul Turner
Paul Turner的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Paul Turner', 18)}}的其他基金
MICA: Identifying risks for severe life-threatening allergic reactions to foods (IRIS-Allergy)
MICA:识别严重危及生命的食物过敏反应的风险(IRIS-Allergy)
- 批准号:
MR/W018616/1 - 财政年份:2022
- 资助金额:
$ 0.96万 - 项目类别:
Research Grant
Exploring mechanisms to optimise the duration of oral immunotherapy for peanut allergy
探索优化花生过敏口服免疫治疗持续时间的机制
- 批准号:
MR/W025639/1 - 财政年份:2022
- 资助金额:
$ 0.96万 - 项目类别:
Research Grant
Improved diagnostics in food allergy (ID-in-FA) Study
改进食物过敏诊断 (ID-in-FA) 研究
- 批准号:
MR/S036954/1 - 财政年份:2019
- 资助金额:
$ 0.96万 - 项目类别:
Research Grant
2013 Microbial Population Biology GRC/GRS
2013年微生物种群生物学GRC/GRS
- 批准号:
1314149 - 财政年份:2013
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Mechanisms underlying the physiological and cellular response to food allergen challenge in human subjects with peanut allergy
花生过敏人类受试者对食物过敏原挑战的生理和细胞反应的机制
- 批准号:
MR/K010468/1 - 财政年份:2013
- 资助金额:
$ 0.96万 - 项目类别:
Fellowship
DISSERTATION RESEARCH: The proximate basis of behavioral plasticity in the butterfly Bicyclus anynana
论文研究:蝴蝶 Bicyclus annana 行为可塑性的直接基础
- 批准号:
1110523 - 财政年份:2011
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Effects of host-use traits on RNA virus evolvability
宿主使用特征对 RNA 病毒进化能力的影响
- 批准号:
1051093 - 财政年份:2011
- 资助金额:
$ 0.96万 - 项目类别:
Continuing Grant
DISSERTATION RESEARCH: Pre-mating experience influences female mate preference in the butterfly Bicyclus anynana
论文研究:交配前经历影响蝴蝶 Bicyclus annana 的雌性交配偏好
- 批准号:
1110382 - 财政年份:2011
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Environmental Variability and Evolution of Virus Specialists and Generalists
环境变化以及病毒专家和通才的进化
- 批准号:
0452163 - 财政年份:2005
- 资助金额:
$ 0.96万 - 项目类别:
Continuing Grant
DISSERTATION RESEARCH: Evolution of Generalism and Specialism in the RNA phage Phi6
论文研究:RNA 噬菌体 Phi6 的通用性和专业性的进化
- 批准号:
0408000 - 财政年份:2004
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
相似国自然基金
Research on Quantum Field Theory without a Lagrangian Description
- 批准号:24ZR1403900
- 批准年份:2024
- 资助金额:0.0 万元
- 项目类别:省市级项目
Cell Research
- 批准号:31224802
- 批准年份:2012
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research
- 批准号:31024804
- 批准年份:2010
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Cell Research (细胞研究)
- 批准号:30824808
- 批准年份:2008
- 资助金额:24.0 万元
- 项目类别:专项基金项目
Research on the Rapid Growth Mechanism of KDP Crystal
- 批准号:10774081
- 批准年份:2007
- 资助金额:45.0 万元
- 项目类别:面上项目
相似海外基金
Doctoral Dissertation Research: Psychosocial Dimensions of the Transition to Civilian Life among Former Combat Veterans
博士论文研究:前退伍军人向平民生活过渡的心理社会维度
- 批准号:
2343316 - 财政年份:2024
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: The role of early life-stage bottlenecks in Arctic benthic fjord communities
博士论文研究:早期生命阶段瓶颈在北极底栖峡湾群落中的作用
- 批准号:
2330851 - 财政年份:2024
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Nutrition, diet, and their influence on survival and reproduction across life
博士论文研究:营养、饮食及其对一生生存和繁殖的影响
- 批准号:
2236173 - 财政年份:2023
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Early Life Adversity and Gut Microbiota Composition
博士论文研究:早期生活逆境和肠道微生物群组成
- 批准号:
2235903 - 财政年份:2023
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Physiological tradeoffs arising from early-life disruption of the gut microbiome
博士论文研究:生命早期肠道微生物组破坏引起的生理权衡
- 批准号:
2142073 - 财政年份:2022
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Financial Technologies, New Financial Markets, and Socio-Economic Life
博士论文研究:金融技术、新金融市场和社会经济生活
- 批准号:
2042955 - 财政年份:2021
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Histories of Stress: A Life Course Approach
博士论文研究:压力的历史:生命历程方法
- 批准号:
2120106 - 财政年份:2021
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Doctoral Dissertation Research in DRMS: A Comparison of Value of Statistical Life Estimates Derived from Revealed and Stated Preferences
DRMS 的博士论文研究:根据显示和陈述的偏好得出的统计寿命估计值的比较
- 批准号:
2116716 - 财政年份:2021
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Roger Bacon's Pharmacology and the Prolongation of Life
博士论文研究:罗杰·培根的药理学与延长生命
- 批准号:
2043555 - 财政年份:2021
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Impacts of early life adversity on bone growth and maintenance
博士论文研究:早年逆境对骨骼生长和维持的影响
- 批准号:
2120962 - 财政年份:2021
- 资助金额:
$ 0.96万 - 项目类别:
Standard Grant