Metal-Peptide Nanoassemblies

金属肽纳米组件

• 批准号: 0455441
• 负责人: Michael Ogawa
• 金额: $ 37.5万
• 依托单位: Bowling Green State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0455441&HistoricalAwards=false
• 关键词: Metal; Peptide; Nanoassemblies

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports Dr. Michael Ogawa at Bowling Green State University to prepare metal-peptide nanostructures having a range of three-dimensional morphologies through: a) using non-crosslinked coiled-coils as the bridging unit, b) varying the coordination geometry of the central metal complexes, c) modifying the peptide sequence by incorporating electrostatic recognition domains to further orient the resulting assemblies, and d) utilizing trigonal coiled-coil architectures to serve as a tri-nuclear bridging ligand to produce a new class of two dimensional metal-peptide dendrimers. These studies embark upon an exploration of the two dimensions of structural diversity that are available to these metal-peptide assemblies: de novo designed peptide conformation and inorganic coordination geometry.This research will assemble novel structures at the nanoscale utilizing principles of coordination chemistry and protein design. The PI participates in the BGSU Academic Investment in Math and Science (AIMS) program, which seeks to increase the number of women and students of color who graduate from BGSU with majors in mathematics, computer, and natural sciences.

无机，生物无机和有机化学计划的这一奖项支持Bowling绿色州立大学的Michael Ogawa博士通过以下方法制备具有一系列三维形态的金属肽纳米结构：a）使用非交联的卷曲螺旋作为桥接单元，B）改变中心金属络合物的配位几何形状，c）通过掺入静电识别结构域来修饰肽序列以进一步定向所得组装体，和d）利用三角卷曲螺旋结构作为三核桥连配体产生一类新的二维金属-肽树状聚合物。这些研究开始探索两个维度的结构多样性，可用于这些金属-肽assemblies.This研究将组装新的结构在纳米级利用配位化学和蛋白质设计的原则从头设计的肽构象和无机配位几何。PI参与了BGSU数学和科学学术投资（AIMS）计划，该计划旨在增加从BGSU毕业的数学，计算机和自然科学专业的女性和有色人种学生的数量。