New Generation Tailored Adsorptive Membranes

新一代定制吸附膜

基本信息

  • 批准号:
    0456831
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-08-01 至 2010-01-31
  • 项目状态:
    已结题

项目摘要

AbstractProposal Title: New Generation Tailored Adsorptive MembranesProposal Number: CTS-0456831Principal Investigator: Ranil WickramasingheInstitution: Colorado State UniversityThe objective of this project is to develop adsorptive membranes as a new, high efficiency unit operation for the recovery and purification of the products of modern molecular biology, such as plasmid DNA, large proteins, and viruses and viral vectors. Novel, high-throughput membranes will be developed as alternative chromatographic supports. Since the feed is pumped through the membrane pores, pore diffusion can be eliminated, leading to binding capacities that are independent of flow rate. As the capacities of adsorptive membranes are equivalent to or greater than those of chromatographic resins, the membrane volume required will be much less than current packed-bed volumes. The research focuses on virus and viral vector purification for gene therapy and vaccine production, as well as virus clearance, which is essential in the production of antibodies and biopharmaceuticals from cell cultures. Five objectives will be pursued: 1) Commercially available membranes and functionalized membranes will be characterized to determine their porosities, pore-size distributions and surface chemistries. Optimized conditions for virus adsorption and the elution of bound viruses will be determined. 2) Non-track-etched membranes will be modified by graft polymerization from the membrane surface. 3) Track-etched membranes will be modified by graft polymerization from the membrane surface. Comparing virus adsorption by track-etched and non-track-etched membranes will provide useful information on the optimum membrane morphology for virus adsorption. 4) Copolymer grafts comprising an ion-exchange monomer and a "spacer" co-monomer will be grown from the membrane surfaces to examine how spatial distribution of ion-exchange sites affects virus binding. 5) A predictive model of practical value for virus clearance will be developed. This model will provide insights into adsorption of viruses not tested here and will include the effects of membrane pore-size distribution. In terms of the broader impacts, the PIs will work with the directors of programs at their institutions that focus on increasing participation in research by undergraduates from underrepresented groups. NSF supplemental award mechanisms such as REU, RET, and international supplements will be sought to support summer undergraduate researchers and teachers in residence and to strengthen the international collaboration. Applications of this research could benefit society by providing breakthrough technologies in bio-purifications.
建议标题:新一代定制吸附膜建议编号:CTS-0456831首席研究员:Ranil Wickramasinghe研究所:科罗拉多州立大学这个项目的目标是开发一种新的、高效的单元操作,用于回收和纯化现代分子生物学的产物,如质粒DNA、大蛋白、病毒和病毒载体。新型的高通量膜将被开发作为替代的层析载体。由于进料是通过膜孔泵送的,因此可以消除孔扩散,从而产生与流速无关的结合能力。由于吸附膜的容量等于或大于层析树脂的容量,所需的膜体积将远远小于目前的填充床体积。这项研究的重点是用于基因治疗和疫苗生产的病毒和病毒载体的纯化,以及病毒清除,这是从细胞培养中生产抗体和生物制药所必需的。将追求五个目标:1)对商用膜和功能化膜进行表征,以确定其孔隙率、孔径分布和表面化学。将确定病毒吸附和结合病毒洗脱的最佳条件。2)对非刻蚀膜进行表面接枝聚合改性。3)采用表面接枝聚合的方法对径迹刻蚀膜进行改性。比较径迹蚀刻膜和非径迹蚀刻膜对病毒的吸附,将为病毒吸附的最佳膜形态提供有用的信息。4)由一个离子交换单体和一个“间隔基”共单体组成的共聚接枝将从膜表面生长出来,以研究离子交换位置的空间分布如何影响病毒结合。5)建立具有实用价值的病毒清除预测模型。这个模型将提供对这里没有测试的病毒的吸附的洞察力,并将包括膜孔径分布的影响。在更广泛的影响方面,私人投资机构将与其机构的项目主任合作,这些项目的重点是增加来自代表性不足群体的本科生对研究的参与。NSF将寻求补充奖励机制,如REU、RET和国际补充资金,以支持夏季本科生研究人员和常驻教师,并加强国际合作。这项研究的应用可以通过在生物净化方面提供突破性技术来造福社会。

项目成果

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Ranil Wickramasinghe其他文献

The effects of buffer condition on the fouling behavior of MVM virus filtration of an Fc‐fusion protein
缓冲液条件对 Fc 融合蛋白 MVM 病毒过滤污染行为的影响
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    Fnu Namila;Da Zhang;Steven J Traylor;Tung Nguyen;Nripen Singh;Ranil Wickramasinghe;X. Qian
  • 通讯作者:
    X. Qian
Cyanide Removal from Wastewater Using Gas Membranes: Pilot–Scale Study
使用气膜去除废水中的氰化物:中试规模研究
  • DOI:
    10.2175/106143004x141537
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    3.1
  • 作者:
    Zhi;B. Han;Ranil Wickramasinghe
  • 通讯作者:
    Ranil Wickramasinghe
Recent progress on sustainable membrane manufacturing with green solvents and biopolymers
使用绿色溶剂和生物聚合物的可持续膜制造的最新进展
  • DOI:
    10.1016/j.coche.2025.101092
  • 发表时间:
    2025-03-01
  • 期刊:
  • 影响因子:
    6.800
  • 作者:
    Chidambaram Thamaraiselvan;Ranil Wickramasinghe
  • 通讯作者:
    Ranil Wickramasinghe
Change Agents: Immediately Implementable Teaching And Educational Hints From The Engineering Education Scholars Program
变革推动者:工程教育学者计划的可立即实施的教学和教育提示
  • DOI:
  • 发表时间:
    1999
  • 期刊:
  • 影响因子:
    0
  • 作者:
    S. Courter;Ruth Lyle;Ranil Wickramasinghe;Lisa Schaefer;K. Nickels;Jodi Reeves;D. Noyce;A. Pearce
  • 通讯作者:
    A. Pearce
Electrocoagulation as a pretreatment for reverse osmosis for potable water from brackish groundwater
电凝聚作为微咸地下水反渗透的预处理
  • DOI:
    10.1016/j.wri.2024.100243
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    5.1
  • 作者:
    Mahmood Jebur;Yu;H. Matsuyama;Ranil Wickramasinghe
  • 通讯作者:
    Ranil Wickramasinghe

Ranil Wickramasinghe的其他文献

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{{ truncateString('Ranil Wickramasinghe', 18)}}的其他基金

Center: IUCRC Phase III University of Arkansas: Center for Membrane Applications, Science and Technology (MAST)
中心:IUCRC 第三阶段 阿肯色大学:膜应用、科学与技术中心 (MAST)
  • 批准号:
    2310905
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
REU Site: From Bench to Market: Engineering Systems for High Efficiency Separations
REU 网站:从实验室到市场:高效分离工程系统
  • 批准号:
    2150436
  • 财政年份:
    2022
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
I-Corps: Catalytic Membrane Reactor for Commercial Production of Biomass-Derived Fuel and Fuel Additives
I-Corps:用于生物质衍生燃料和燃料添加剂商业化生产的催化膜反应器
  • 批准号:
    1954437
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Phase II IUCRC at University of Arkansas: Center for Membrane Science, Engineering and Technology (MAST)
阿肯色大学 IUCCRC 第二期:膜科学、工程和技术中心 (MAST)
  • 批准号:
    1822101
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
I/UCRC: University of Arkansas Membrane Science, Engineering and Technology (MAST) Center Site Proposal
I/UCRC:阿肯色大学膜科学、工程与技术 (MAST) 中心选址提案
  • 批准号:
    1361809
  • 财政年份:
    2014
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
Planning Grant: I/UCRC for Formation of new MAST Center Site at the University of Arkansas
规划拨款:I/UCRC 用于在阿肯色大学建立新的 MAST 中心场地
  • 批准号:
    1266060
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Advanced Responsive Low-Fouling Membranes for Water Treatment
用于水处理的先进响应低污染膜
  • 批准号:
    1066505
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Student Travel Support for the 2009 North American Membrane Society Annual Meeting in Charleston, SC June 20-24, 2009
为 2009 年 6 月 20-24 日在南卡罗来纳州查尔斯顿举行的 2009 年北美膜协会年会提供学生旅行支持
  • 批准号:
    0917127
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Travel Support for Engineering with Membranes Conference
膜工程会议差旅支持
  • 批准号:
    0824097
  • 财政年份:
    2008
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
New Generation Responsive Membranes for Water Treatment
新一代水处理响应膜
  • 批准号:
    0651646
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:
    Standard Grant

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