Collaborative Research: A Novel Approach to Improve the Interfacial Strength of Hydroxyapatite Coated Implants for Orthopedic and Dental Applications

合作研究：提高骨科和牙科应用羟基磷灰石涂层植入物界面强度的新方法

• 批准号: 0500269
• 负责人: Mei Wei
• 金额: --
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0500269&HistoricalAwards=false
• 关键词: Collaborative; Research; Novel; Approach; Improve

The objective of the research is to understand the interrelationship between the interface modification and the final performance of the HA coating. Such coatings should have a strong bonding strength, stable interface, superior corrosion resistance and excellent biocompatibility suitable for orthopedic and dental applications. The proposed approach is to modify the Ti alloy surface prior to HA coating. A multifunctional compliant multi-layer will be applied to the surface of the Ti alloy, which consists of a FeCrAl thin film bottom layer, a dense, adherent alpha-alumina subscale, and a nano-whisker alumina top layer. Futhermore, nano HA coatings will be applied onto the surface of the compliant layer using either electrophoresis or biomimetic assembly. Both coating techniques will be explored as model systems for comparison. The proposed project has a broader societal impact on various scientific disciplines. Not only will it deliver a new type of implant material with superior performance for better healthcare, but will also give new insights to overcome the long-standing problems of poor metal-ceramic bonding. The nano-engineered metal surface could also provide a new template for micro-electro-mechanical systems (MEMS) and nano-electro-mechanical systems (NEMS) applications, such as sensors and actuators for harsh environment and drug delivery devices. This project will result in the training of a number of graduate and undergraduate students in the area of biomaterial interface studies, while exposing them to multidisciplinary inter-university (UConn-UCF) collaboration. In addition, we will perform K-12 outreach to get high school teachers and students, especially female and under-representative minorities, excited about engineering research.

研究的目的是了解界面改性和HA涂层的最终性能之间的相互关系。 这种涂层应具有强的结合强度、稳定的界面、上级耐腐蚀性和适合于矫形和牙科应用的优异的生物相容性。提出的方法是在HA涂层之前对钛合金表面进行改性。 将多功能顺应性多层应用于钛合金的表面，其由FeCrAl薄膜底层、致密的粘附性α-氧化铝基底和纳米晶须氧化铝顶层组成。 此外，纳米HA涂层将使用电泳或仿生组装施加到顺应层的表面上。 这两种涂层技术将作为模型系统进行探索以进行比较。拟议的项目对各种科学学科产生了更广泛的社会影响。 它不仅将提供一种具有上级性能的新型植入材料，以实现更好的医疗保健，而且还将为克服长期存在的金属陶瓷结合不良的问题提供新的见解。纳米工程金属表面还可以为微机电系统（MEMS）和纳米机电系统（NEMS）应用提供新的模板，例如用于恶劣环境和药物输送设备的传感器和致动器。该项目将导致一些研究生和本科生在生物材料界面研究领域的培训，同时让他们接触到多学科大学间（UConn-UCF）的合作。 此外，我们将进行K-12推广，让高中教师和学生，特别是女性和代表性不足的少数民族，对工程研究感到兴奋。