GOALI: Multi-functional composites for load-bearing skeletal applications

GOALI：用于承重骨骼应用的多功能复合材料

• 批准号: 0503315
• 负责人: Mei Wei
• 金额: $ 30万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0503315&HistoricalAwards=false
• 关键词: GOALI; Multi; functional; composites; load

Wie0503315ABSTRACTIn this BME/RAPD/GOALI initiative program, the applicants will explore a new apatite/fibrouspolymer composite featuring a Young's modulus matched to natural bone, sufficient mechanicalstrength to support reasonable loads during the healing process, excellent biocompatibility,capability of controlled release of drugs, good osteoconductivity and osteoinductivity to enhanceboth bone formation and ingrowth, appropriate degradation rate, and capability of being replacedby natural bone in a long-term. The specific objectives are:o To prepare bone-like carbonated hydroxyapatite (CHA)/ fibrous polymer composites withYoung's modulus and mechanical strength matching that of cortical bone using novelpolymer-braid constructions.o To obtain excellent biocompatibility and osteoconductivity of the composite by biomimeticformation of bone-like CHA on the surface of polymer fibers.o To explore the possibility of using the novel constructions proposed in the study as a moresophisticated drug delivery system.o To understand the interrelationship between the composite mechanical properties and thefiber composition, fiber surface modification, formation of trans-crystallinity, and CHAloading by conducting systematic experimental work and comparing the data with thepredictions of theory.o To gain an in-depth knowledge of the effect of the composite composition, construction,and geometry on the bone formation rate on the composite using a series of cell cultureassays.

摘要：在BME/RAPD/GOALI项目中，申请人将探索一种新的磷灰石/纤维聚合物复合材料，其杨氏模量与天然骨相匹配，具有足够的机械强度以在愈合过程中支持合理的负荷，具有优异的生物相容性，药物控释能力，良好的骨导电性和骨诱导性以促进骨形成和长入，适当的降解率。以及长期被天然骨骼替代的能力。具体目标是：o利用聚合物编织结构制备具有杨氏模量和机械强度与皮质骨相匹配的骨样碳化羟基磷灰石(CHA)/纤维聚合物复合材料。o通过在聚合物纤维表面仿生学地形成骨样CHA，获得复合材料优异的生物相容性和骨导电性。o探索将研究中提出的新结构用作更复杂的药物输送系统的可能性。通过系统的实验工作，并将数据与理论预测进行比较，了解复合材料的力学性能与纤维成分、纤维表面改性、反晶态的形成和chaloding之间的相互关系。o通过一系列细胞培养试验，深入了解复合材料的成分、结构和几何形状对复合材料骨形成率的影响。