Biofunctionalized addressable polyelectrolyte based nanoparticles for the controlled release of drugs related to hard tissue regeneration ((06) M07)

在TP M7中，与M1、M2、M3、M4、M5、M9合作，进一步改进了已建立的药物递送系统（DDS），涉及骨替代材料（BSM）的功能化模式，并与B1、B5、B7、B13、B14合作，涉及新的生物学任务。在化学和分析工作包AP 1中，集成了用于可切换和多模式药物释放的化学反应性和温度响应性聚合物单元以及用于进一步特异性相互作用的生物配体、抗体和RNA。在生物工作包AP 2中，研究了用优化DDS官能化的BSM与细胞培养物和动物模型的相互作用。

In TP M7 the established drug delivery systems (DDS) are further improved in cooperation with M1, M2, M3, M4, M5, M9 concerning functionalization modalities of bone substituting materials (BSM) and in cooperation with B1, B5, B7, B13, B14 concerning novel biological tasks. In the chemical and analytical working package AP1 chemically reactive and thermoresponsive polymer units for switchable and multimodal drug release as well as biological ligands, antibodies and RNA for further specific interactions are integrated. In the biological working package AP2 the interaction of the BSM functionalized with optimized DDS with cell cultures and animal models is studied.