Biofunctionalized addressable polyelectrolyte based nanoparticles for the controlled release of drugs related to hard tissue regeneration ((06) M07)

用于硬组织再生相关药物控制释放的生物功能化可寻址聚电解质纳米颗粒 ((06) M07)

• 批准号: 170723691
• 金额: --
• 依托单位: Leibniz-Institut für Polymerforschung Dresden (IPF)
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/170723691?language=en
• 关键词: Biofunctionalized; addressable; polyelectrolyte; based; nanoparticles

In TP M7 the established drug delivery systems (DDS) are further improved in cooperation with M1, M2, M3, M4, M5, M9 concerning functionalization modalities of bone substituting materials (BSM) and in cooperation with B1, B5, B7, B13, B14 concerning novel biological tasks. In the chemical and analytical working package AP1 chemically reactive and thermoresponsive polymer units for switchable and multimodal drug release as well as biological ligands, antibodies and RNA for further specific interactions are integrated. In the biological working package AP2 the interaction of the BSM functionalized with optimized DDS with cell cultures and animal models is studied.

在TP M7中，与M1，M2，M3，M4，M4，M5，M9合作进一步改善了有关骨骼替代材料（BSM）的功能化模态，并与B1，B5，B7，B7，B13，B14处理新型生物学任务。在化学和分析工作包中，AP1的化学反应性和热响应聚合物单元，用于可切换和多模式药物释放以及生物配体，抗体和RNA，用于进一步的特定相互作用。在生物工作包AP2中，研究了BSM与优化DDS与细胞培养物和动物模型的BSM相互作用。