NIRT: Aerogels and Related Nanoporous Materials for Biological Membranes

本项目是由一个多学科国际团队进行的一项研究，旨在通过计算和实验方法对组装在气凝胶上的纳米生物结构的合成和功能进行基本理解。脂质双分子层和生物分子将被组装在气凝胶支架上，形成各种功能的生物膜。气凝胶底物与其他支撑结构相比具有优势，因为合成膜的每个组分都可以像在活细胞膜中一样获得生物活性材料。研究的三个领域是：具有定制化学和结构的气凝胶表面的合成，合成细胞膜样脂质纳米组件的创建，以及膜与生物活性分子相互作用的多尺度计算模型。将大力强调调查人员之间的沟通和纳入不同的代表性不足的群体。

0506602RisbudThis project is a study by a multidisciplinary international team for the development of a fundamental understanding of the synthesis and functionality of nanobiostructures assembled on aerogels using computational and experimental approaches. Lipid bilayers and biomolecules will be assembled on aerogel supports to form biomembranes of various functionalities. The aerogel substrate confers an advantage over other support structures since each component of the synthetic membrane has access to biologically active materials as in a living cell membrane. The three areas of investigation are: synthesis of aerogel surface with tailored chemistry and structure, creation of synthetic cell membrane-like lipid nano-assemblies, and multi-scale computational modeling of the interaction of the membranes with biologically active molecules. Communication between investigators and inclusion of diverse underrepresented groups will be strongly emphasized.