NIRT: Aerogels and Related Nanoporous Materials for Biological Membranes

NIRT：用于生物膜的气凝胶和相关纳米多孔材料

• 批准号: 0506602
• 负责人: Subhash Risbud
• 金额: --
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0506602&HistoricalAwards=false
• 关键词: NIRT; Aerogels; Related; Nanoporous; Materials

0506602RisbudThis project is a study by a multidisciplinary international team for the development of a fundamental understanding of the synthesis and functionality of nanobiostructures assembled on aerogels using computational and experimental approaches. Lipid bilayers and biomolecules will be assembled on aerogel supports to form biomembranes of various functionalities. The aerogel substrate confers an advantage over other support structures since each component of the synthetic membrane has access to biologically active materials as in a living cell membrane. The three areas of investigation are: synthesis of aerogel surface with tailored chemistry and structure, creation of synthetic cell membrane-like lipid nano-assemblies, and multi-scale computational modeling of the interaction of the membranes with biologically active molecules. Communication between investigators and inclusion of diverse underrepresented groups will be strongly emphasized.

这个项目是一个多学科国际团队的研究，目的是利用计算和实验方法，对在气凝胶上组装的纳米生物结构的合成和功能有一个基本的了解。脂质双层和生物分子将组装在气凝胶载体上，形成具有各种功能的生物膜。气凝胶基质比其他支撑结构具有优势，因为合成膜的每个成分都可以获得生物活性物质，就像在活细胞膜中一样。这三个领域的研究是：合成具有特定化学和结构的气凝胶表面，创造合成的细胞膜样脂纳米组装，以及膜与生物活性分子相互作用的多尺度计算模拟。将大力强调调查人员之间的沟通和纳入不同的任职人数不足的群体。