NER: Anisotropic Nanocolloid Manufacturing By Nanofluidic Processing

NER：通过纳米流体加工制造各向异性纳米胶体

• 批准号: 0507839
• 负责人: Michael Solomon
• 金额: $ 10万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0507839&HistoricalAwards=false
• 关键词: NER; Anisotropic; Nanocolloid; Manufacturing; Nanofluidic

ABSTRACT - 0507839University of MichiganNER: Anisotropic Nanocolloid Manufacturing By Nanofluidic ProcessingMichael J. Solomon, Mark A. Burns and Joanna Mirecki Millunchick, University of MichiganThe assembly of nanocolloids into useful structures is key to emergent applications of nanoscale science and engineering. Yet, the initial impact of assembly has been limited because of the disappointingly small number of unit cells assembled to date. Because of their reduced symmetry relative to spheres, ready availability of nanocolloids with anisotropic shape and interactions would improve the scope for assembly of ordered arrays with novel morphology. However, the development of methods to produce anisotropic particles is in its infancy. Methods available are laborious and/or capital intensive and often neither flexible nor scalable. Here we will develop a versatile nanofluidic platform for the rapid manufacture of nanocolloids with anisotropic shape and interactions. This exploratory project combines an interdisciplinary team with strong capabilities in particle synthesis, lithography, fluidics and focused ion beam (FIB) patterning in pursuit of this aim.On chip fluidic processing is an efficient way to direct, mix, react and analyze minute amounts of reactants and products. We aim to apply nanofluidic technology to direct, order and link chains of individual nanocolloids in nanoscale channels. The ordering and linking will provide the desired shape and interaction anisotropy. Nanofabrication and FIB methods will be used to construct a nanofluidic processor that can be replicated into parallel processors for large-scale production. Through syntheses of monodisperse nanocolloids of poly(methyl methacrylate) and silica with different steric layer chemistry, we have available particles with differing potential interactions, here labeled as nanocolloids "A" and "B." Their size is controlled and as small as 40 nm. The proposed nanofluidic processor will yield linked, permanently bonded chains of nanocolloids with ordering of A and B that is variable and specifiable. Our initial aim, for example, will be to produce a "nano-surfactant" of type B-B-A-A-A-A. The device function will be: By a software-programmed sequence of pressure actuations, A and B particles are alternately fed single-file to a narrow channel in the desired sequence. Matching the channel cross-section to the particle diameter yields single-file motion that conserves the sequence order. The particles are then conveyed into a reaction zone where a flow constriction immobilizes and compresses the sequence so that adjacent particles are in contact. A surface coupling reaction (initiated by UV excitation) then covalently binds the particles into the anisotropic sequence specified by the fluidic ordering. The device will first be developed at scales of ~ 500 nm so that fluidic control and operation can be optimized through in situ visualization with two-channel confocal fluorescence microscopy. The device will then be scaled down for manufacturing with ~ 50 nm building blocks. The products of the manufacturing will be used to perform initial assembly studies.Our idea to apply nanofluidics for nanocolloid synthesis has intellectual merit because: (1) fluidic processing allows precise control of the relative orientation of particles needed for high fidelity synthesis; (2) the scheme uses continuous (rather than batch) processing and thus achieves a true manufacturing capability. The materials will be used for initial fundamental engineering science studies of anisotropic particle assembly that could not be accomplished in any other way. In addition to the outcomes of graduate education and outreach to middle school girls, the broader impact of the work will be to establish that nanofluidics and nanopatterning can be applied to solve a difficult problem in nanocolloid synthesis. The project will: (1) make possible routine synthesis of anisotropic particles in academic laboratories, thereby increasing the scope for assembly studies nationwide; (2) render feasible the possibility of large-scale, commercial manufacturing of specialty anisotropic nanocolloids for such applications as chemical sensing and photonic band gap materials. The principal research and education theme that this proposal addresses is "Manufacturing processes at the nanoscale."

摘要-0507839密歇根州的University：纳米荧光处理的各向异性纳米胶体制造，Mark A. Solomon，Mark A. Burns和Joanna Mirecki Millchick，密歇根大学，纳米机固醇大会的纳米固定结构的重要结构是纳米级科学和发动机的重要结构的关键。然而，由于迄今为止组装的少量单位单元格，组装的最初影响受到限制。由于它们相对于球体的对称性减少，因此具有各向异性形状和相互作用的纳米胶体的可用性将提高与新形态组装有序阵列的范围。但是，产生各向异性颗粒的方法的发展仍处于起步阶段。可用的方法是费力的和/或资本密集型的​​，通常既不灵活也不可扩展。在这里，我们将开发一个多功能的纳米流体平台，用于快速生产具有各向异性形状和相互作用的纳米胶体。这个探索性项目结合了一个跨学科团队，具有强大的粒子合成，光刻，流体和聚焦离子束（FIB）的功能，以实现这一目标。在芯片流体处理中，是一种有效的方式，是指导，混合，混合，反应，反应和反应和分析的抗压剂和产品。我们旨在将纳米流体技术应用于纳米级渠道中的单个纳米胶体的指导，顺序和连接链。排序和链接将提供所需的形状和相互作用各向异性。纳米化和FIB方法将用于构建一个纳米流体处理器，可以将其复制到并行处理器中以进行大规模生产。通过与不同空间层化学的聚（甲基丙烯酸甲酯）和二氧化硅的单分散纳米胶体的合成，我们具有具有不同潜在相互作用的可用颗粒，在这里标记为纳米胶体“ A”和“ B.”。它们的大小是控制的，小至40 nm。拟议的纳米流体处理器将产生纳米胶体的永久粘结链，并通过可变且可定义的A和B订购。例如，我们的最初目标是生产B-B-A-A-A-A-A型的“纳米表面活性剂”。设备函数将是：通过压力驱动的软件编程序列，A和B颗粒在所需序列中交替喂入单文件至狭窄的通道。将通道横截面与颗粒直径匹配的单文件运动可以节省序列顺序。然后将颗粒传递到一个反应区域，在该区域中，流动收缩固定并压缩了序列，以使相邻的颗粒接触。然后，表面偶联反应（通过紫外线激发引发）然后共价结合颗粒与流体有序指定的各向异性序列。该设备将首先以〜500 nm的尺度开发，以便可以通过两道通道共聚焦荧光显微镜通过原位可视化来优化流体控制和操作。然后，将将设备缩放为使用〜50 nm的构建块制造。制造的产物将用于进行初步的组装研究。我们的想法将纳米荧光剂用于纳米胶体合成具有智力优点，因为：（1）流体处理可以精确控制高保真度合成所需的颗粒所需的粒子的相对方向； （2）该方案使用连续（而不是批次）处理，从而实现了真正的制造能力。这些材料将用于各向异性颗粒组件的初始基础工程科学研究，这些研究无法以其他方式完成。除了研究生教育的结果和与中学女生的宣传外，这项工作的广泛影响还将确定纳米流体和纳米图案可以应用于解决纳米胶体合成中的困难问题。该项目将：（1）使学术实验室中各向异性颗粒的常规合成，从而增加了全国的集会研究范围； （2）使大规模的特种各向异性纳米胶体的大规模商业制造可行，以用于化学传感和光子带隙材料等应用。该提案提出的主要研究和教育主题是“纳米级的制造过程”。