Wafer-scale bio/nano filament assembly for chem/bio sensors

纳米技术的一个主要挑战是高堆积密度的纳米/生物分子的晶圆级组装，理解和模拟细胞的力学是当前纳米技术的主要挑战之一。复合电场和诱导分子实现其组装的力，将用内沉积有限元法进行分析。成像方法将被用于调查组装结果。也许是最有价值的，本世纪未来几十年的任务。这项任务是复杂的，因为机械行为是通过一系列尺度的相互作用而出现的，模型必须反映这些尺度，这样它们才能最终成为“第一原理”模型，从而能够预测各种机械行为。其智力优势将体现在以下三个尺度上：(1)纳米/生物分子的晶圆尺度组装；(2)生物丝悬浮液的力学；以及成像工具的开发，使扫描电镜，AFTEM， AFM成像；(3)装配过程建模仿真工具的开发；(4)对电场驱动力的理解。整个细胞的粗粒度模型。将采用分层建模方法：a)生物丝的材料特性将从原子尺度传递到生物丝悬浮液尺度；b)活性细胞材料的有效特性将通过粗粒度生物丝悬浮液模拟传递到细胞迁移的连续尺度模拟。并发多尺度耦合方案将在两个层次上发展：a)。虽然信息将主要通过传递属性信息在尺度之间传递，但将连续介质力学与分子力学联系起来的并发耦合方案将被开发出来，从而在某些应用中实现原子运动与生物纤维特性的直接耦合。b)一种新的混合模拟方案，该方案解决了细胞运动的连续介质方程，并通过执行生物丝悬浮模拟同时解决了局部细胞骨架结构。将开发和测试用于生物/化学传感器的单个分子装置。我们小组正在制造一种新的NEMS设备来测量细胞力，将用于测量牵引力和细胞纤维结构的同时成像。这将启动分子尺度生物/化学传感器的大规模发展，最终可以大规模生产。细胞运动的模拟…此外，在更大的尺度上，我们将开发新的模型，从生物丝悬浮液的力学模型中获得粗粒度的活性应力，从而考虑生物流-结构效应、静电相互作用、热行为以及聚合和解聚。

150 WORD PROJECT SUMMARYA major challenge in nanotechnology is wafer-scale assembly of nano/bio molecules with the high packing density Understanding and modeling the mechanics of the cell is one of the major challengesin current nanotechnology.. A composite electric field and the forces induced on molecules to achieve their assembly, will be will be analyzed with the inmmersedImmersed FEM method. Imaging methods will be accompaniedcombinedused to investigate the assembly results. , and yet probably most rewarding, tasks of the present centurynext few decades. The task is complex, for the mechanical behavior emerges through an interaction of a hierarchy of scales, and it is essential for models to reflect these scales so that they can eventually become "first-principles" models that enable predictions of a large variety of mechanical behavior. The intellectual merits will beare the following3D simulation tools to be developed will span three scaless: (1) wafer-scale assembly of nano/bio molecules; (2) mechanics of bio-filament suspensions; and development of imaging tools to enable imaging by for SEM,, AFTEM, and AFM; (3) development of modeling simulation tools for assembly process modeling; and (4) understanding of electric field driven forces. coarse-grained models of the entire cell. An hierarchical modeling approach will be taken bewhere: a) material properties of bio-filaments will be passed from the atomic scale to the bio-filament suspension scale, and b) the effective properties of the active cell material will be passed on to the continuum scale simulations of cell migration by coarse graining the bio-filament suspension simulations. Concurrent multiscale coupling schemes will be developed at two levels: a) . Although information will be transferred between the scales primarily by passing property information, concurrent coupling schemes linking continuum mechanics to molecular mechanics will be developed that enable direct coupling of atomistic motions to biofiber properties in some applications, and b) a new hybrid simulation scheme that solves the continuum equations for cell motion and concurrently resolves the local cytoskeletal structure by performing bio-filament suspension simulations.Individual molecular devices will be developed and tested foras bio/chemical sensors.A novel NEMS device to measure cellular forces, being fabricated in our group, will be used for the measurements of traction forces and the simultaneous imaging of the fibrous structure of the cell. This will initiate the development of molecular scale bio/chemical sensors in a massthat ultimately could be mass-producedproducible way. the simulation of cell motility.. Also, at a larger scale, we will develop new models to obtain coarse-grained active stresses from mechanical models of bio-filament suspensions, thereby accounting for bio-fluid-structure effects, electrostatic interactions, thermal behavior and polymerization and depolymerization.