SBIR Phase I: Disposable pL Fluid Transfer/Microarray Printing Device

SBIR 第一阶段：一次性 pL 流体转移/微阵列打印设备

• 批准号: 0512908
• 负责人: Robert Haushalter
• 金额: --
• 依托单位: Parallel Synthesis Technologies, Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0512908&HistoricalAwards=false
• 关键词: SBIR; Phase; Disposable; pL; Fluid

This Small Business Innovation Research Phase I Project proposes to develop a disposable polymer based microarray printing device that will cost a small fraction of the current state of the art devices and at the same time offer significant improvements in reliability and performance. In spite of wide spread use for microcontact printing of DNA and protein microarrays, the manually manufactured, sharpened metal pins used for array fabrication remain very expensive both in terms of purchase cost and constant maintenance and cleaning. Polymer pins will be manufactured using a combination of silicon micromachining and electroforming to prepare a very high precision positive micromold, which will be needed to produce the fine features necessary to control fluid flow to the printing tip. The commercial application of the proposed plastic pins will be on a broad range of biological research activities that use printed microarrays. Some of the advantages of the product will include better wettability, parallel manufacturing, very precise dimensions, capability to form smaller and more uniform spots, disposable, and availability at less than 0.5% of the current cost of metal pins.

这个小型企业创新研究第一阶段项目建议开发一种基于一次性聚合物的微阵列打印设备，该设备的成本将是目前最先进设备的一小部分，同时在可靠性和性能方面提供显着改进。尽管DNA和蛋白质微阵列的微接触打印广泛使用，但用于阵列制造的手工制造的锐化金属引脚在购买成本和持续维护和清洁方面仍然非常昂贵。聚合物引脚将使用硅微加工和电铸的组合来制造，以制备非常高精度的正微模具，这将需要产生控制流体流向印刷尖端所需的精细特征。拟议的塑料大头针的商业应用将广泛应用于使用印刷微阵列的生物研究活动。该产品的一些优点包括更好的润湿性、并行制造、非常精确的尺寸、形成更小更均匀的斑点的能力、一次性以及可用性，其成本低于目前金属引脚的0.5%。