SBIR Phase II: Disposable pL Fluid Transfer/Microarray Printing Device

SBIR 第二阶段：一次性 pL 流体转移/微阵列打印设备

• 批准号: 0646638
• 负责人: Robert Haushalter
• 金额: --
• 依托单位: Parallel Synthesis Technologies, Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-15 至 2010-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0646638&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Disposable; pL

This Small Business Innovation Research (SBIR) Phase II project provides an inexpensive disposable polymer tool that will perform extremely accurate fluid transfer in the picoliter to nanoliter range. Research efforts have already demonstrated that the costs associated with fabricating molds employing a combination of silicon micromachining and electroforming will allow these tools to be disposable. Fabrication processes will be transitioned to injection molding by adapting the micromachined/electroformed molds to the injection process. The research will design the final generations of the printing and fluid transfer pin designs, use silicon micromachining and electroforming to prepare the injection molds for the 96 and 384 pin printheads, design new collimator / printheads for both microarray printing and fluid transfer applications and redesign and scale up the chemical surface treatment process to treat thousands of pins simultaneously. Because the polymer pins can be manufactured so inexpensively compared to current technology, the number of laboratories around the world that can utilize this nanoscale fluid handling will dramatically increase.The broader impacts of this project will be to provide disposible plastic parts at less than ten percent of the least expensive current technology thereby enabling reductions in costs for high throughput technologies important to drug discovery and diagnostics. This could improve the delivery of healthcare to the nation and reduce its overall cost.

这个小型企业创新研究（SBIR）第二阶段项目提供了一种廉价的一次性聚合物工具，将在皮升到纳升范围内执行极其精确的流体转移。研究工作已经证明，与采用硅微加工和电铸的组合制造模具相关的成本将允许这些工具是一次性的。制造过程将过渡到注塑成型，通过调整微加工/电铸模具的注射过程。该研究将设计最后几代的打印和流体转移针设计，使用硅微加工和电铸来准备96和384针打印头的注塑模具，为微阵列打印和流体转移应用设计新的准直器/打印头，并重新设计和扩大化学表面处理工艺，以同时处理数千个针。与现有技术相比，聚合物针的制造成本非常低，因此世界各地能够利用这种纳米级流体处理的实验室数量将大幅增加。该项目的更广泛影响将是提供一次性塑料部件，其成本不到当前最便宜技术的10%，从而降低对药物发现和诊断至关重要的高通量技术的成本。 这可以改善向国家提供的医疗保健服务，并降低其总体成本。