Biophotonics: Membranes as Motors: Investigating Nanoelectromechanical Characteristics
Biophotonics: Membranes as Motors: Investigating Nanoelectromechanical Characteristics
批准号:
0522862
负责人:
Bahman Anvari
金额:
$0.0万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-09-01 至 2007-09-30
中文摘要
申请人的主要目标是了解细胞膜中电诱导皮牛顿级力产生的机制,以及通过膜电/机械特性和跨膜蛋白(如prestin)和阴离子两亲性剂(如solicyate)的相互作用来调节这一过程的分子基础。具体目标包括:(1)研究在没有prestin和细胞骨架的情况下,膜表面电荷和张力对电致力产生的影响;(2)利用模型野生型人胚胎肾(HEK)细胞和转染:(a) prestin、(b)突变prestin和(c)与prestin密切相关的其他蛋白的HEK细胞,研究prestin对整体电诱导力产生的贡献;(3)利用加入到膜中的电压敏感荧光染料研究机电互易性。
英文摘要
0522862AnvariABSTRACTThe applicant's main objectives are to understand the mechanism(s) of the electrically-induced piconewton level force generation in cell membranes and the molecular basis for modulation of this process through membrane electrical/mechanical properties and the interaction of transmembrane proteins such as prestin and anionic amphipathic agents such as solicyate. Specific objectives include: (1) Investigate the effects of membrane surface charge and tension on electrically-induced force generation in the absence of both prestin and the cytoskeleton; (2) Investigate the contribution of prestin to the overall electrically-induced force generation using model wildtype human embryonic kidney (HEK) cells, and HEK cells transfected with: (a) prestin, (b) mutated prestin, and (c) other proteins closely-related to prestin; and (3) Investigate electromechanical reciprocity using a voltage sensitive fluorescent dye incorporated into the membrane.
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