EAGER: Dual magnetic resonance and optical modalities for image-guided early detection, staging, and resection of ovarian tumors

EAGER：双磁共振和光学模式用于卵巢肿瘤的图像引导早期检测、分期和切除

• 批准号: 1940965
• 负责人: Bahman Anvari
• 金额: $ 30万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-11-15 至 2023-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1940965&HistoricalAwards=false
• 关键词: EAGER; Dual; magnetic; resonance; optical

Ovarian cancer is the deadliest gynecological cancer in women. Most women are diagnosed at the late stage of the disease. Surgical removal of tumors followed by chemotherapy is the gold standard to treat ovarian cancer. Currently, there is no sufficiently accurate screening method for early detection of ovarian cancer. The investigators propose to develop a dual imaging modality based on magnetic resonance and flourescene for early detection, staging, and image guided-removal of ovarian tumors. Feasiblity of the proposed approach will be tested in animal models of ovarian cancer. The proposed approach may ultimately enable early detection of ovarian cancer, and improve survival. Under this EAGER proposal, the investigators propose to explore the transformative potential of a dual imaging modality agent using magnetic resonance (MR) and fluorescence for early detection, staging, and guided-resection of ovarian tumor implants. This dual imaging modality method is based on an innovative liposomal nanoparticle system that contains gadolinium (Gd), and a new brominated cyanine dye (BrCy106) as the respective MR and optical contrast agents. The long-term goal of the investigators is to develop imaging methods with high sensitivities for both early detection and localization of small ovarian tumors prior to surgery by MR imaging (MRI), followed by near infrared fluorescence imaging (NIRFI) at surgery to aide staging and guide surgical removal of all tumors which cannot otherwise be visualized.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

卵巢癌是女性最致命的妇科癌症。大多数妇女在疾病的晚期被诊断出来。手术切除肿瘤后进行化疗是治疗卵巢癌的金标准。目前，还没有足够准确的筛查方法来早期发现卵巢癌。研究人员建议开发一种基于磁共振和荧光的双重成像模式，用于卵巢肿瘤的早期检测、分期和图像引导切除。所提出的方法的可行性将在卵巢癌动物模型中进行测试。所提出的方法最终可能使卵巢癌的早期检测成为可能，并提高生存率。根据EAGER的提议，研究人员提议探索使用磁共振（MR）和荧光的双成像模式试剂的变革潜力，用于卵巢肿瘤植入物的早期检测、分期和引导切除。这种双成像模式方法是基于一种创新的脂质体纳米颗粒系统，含有钆（Gd），和一种新的溴化花菁染料（BrCy106）作为各自的MR和光学造影剂。研究人员的长期目标是开发具有高灵敏度的成像方法，用于在手术前通过MR成像（MRI）对小卵巢肿瘤进行早期检测和定位，近红外荧光成像（NIRFI）该奖项反映了NSF的法定使命，并被认为是值得支持的，使用基金会的知识价值和更广泛的影响审查标准进行评估。

项目成果

Indocyanine Green (ICG) Fluorescence Is Dependent on Monomer with Planar and Twisted Structures and Inhibited by H-Aggregation.

• DOI: 10.3390/ijms241713030
• 发表时间: 2023-08-22
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
• 影响因子: 5.6
• 作者: Chon, Bonghwan;Ghann, William;Uddin, Jamal;Anvari, Bahman;Kundra, Vikas
• 通讯作者: Kundra, Vikas

Membrane cholesterol enrichment and folic acid functionalization lead to increased accumulation of erythrocyte-derived optical nano-constructs within the ovarian intraperitoneal tumor implants in mice

• DOI: 10.1016/j.nano.2023.102728
• 发表时间: 2023-12-11
• 期刊: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
• 影响因子: 5.4
• 作者: Lee，Chi-Hua;Mac，Jenny;Anvari，Bahman
• 通讯作者: Anvari，Bahman