UNS:Erythrocyte-derived optical nano-vesicles as photo-theranostic agents

UNS：红细胞来源的光学纳米囊泡作为光治疗剂

• 批准号: 1509218
• 负责人: Bahman Anvari
• 金额: $ 35.58万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2020-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1509218&HistoricalAwards=false
• 关键词: UNS; Erythrocyte; derived; optical; nano

PI: Anvari, BahmanProposal No.: 1509218The unique contribution of this proposed work is the ability to engineer nanoparticles that can be made using the patient's own erythrocytes to extend the circulation time and minimize biocompatibility issues so that these nanoparticles can interact with tumors. Light energy can then be used with the nanoparticles to generate heat and provide localized hyperthermia at the tumor to destroy it or augment chemo or radiotherapy. Personalized medicine has great potential and this work can make important contributions to this field.Effective treatment with a minimum of side effects of various malignant tumors remains an important problem in modern medicine. Personalized medicine gives the opportunity to direct and optimize such treatment to individual patients based upon their genetic and immunological makeup. This proposal will develop ghost erythrocytes loaded with fluorescent dyes as theranostic agents to image cancer cells by fluorescence and also to induce photothermal killing damage. The erythrocytes will be functionalized with an antibody to target tumors in vivo in xenograft mouse models. The PI has had many under-represented students in his lab. Aspects of the work will be incorporated into a new class.

PI：Anvari，巴林Proposal No：1509218这项拟议工作的独特贡献是能够利用患者自己的红细胞制造纳米颗粒，以延长循环时间并将生物兼容性问题降至最低，从而使这些纳米颗粒能够与肿瘤相互作用。然后，光能可以与纳米颗粒一起使用来产生热量，并在肿瘤处提供局部热疗，以摧毁它或加强化疗或放射治疗。个性化医疗具有巨大的潜力，这项工作可以为这一领域做出重要贡献。有效地治疗各种恶性肿瘤的副作用最小仍然是现代医学中的一个重要问题。个性化医学提供了根据患者的遗传和免疫构成指导和优化此类治疗的机会。这项提议将开发负载荧光染料的幽灵红细胞作为治疗药物，通过荧光对癌细胞成像，并诱导光热杀伤性损伤。在异种小鼠模型中，红细胞将被体内靶向肿瘤的抗体功能化。PI在他的实验室里有许多代表不足的学生。这项工作的各个方面将被并入一个新的类别。