UNS:Erythrocyte-derived optical nano-vesicles as photo-theranostic agents

PI：Anvari，Bahman提案编号：1509218这项拟议工作的独特贡献是能够设计纳米颗粒，这些纳米颗粒可以使用患者自己的红细胞来延长循环时间并最大限度地减少生物相容性问题，以便这些纳米颗粒可以与肿瘤相互作用。然后，光能可以与纳米颗粒一起使用，以产生热量并在肿瘤处提供局部热疗，以破坏肿瘤或增强化疗或放疗。个体化医疗具有巨大的发展潜力，对这一领域的研究具有重要的意义，如何有效地治疗各种恶性肿瘤，并使其副作用最小化，是现代医学的重要课题。个性化医疗提供了根据患者的遗传和免疫组成指导和优化个体患者治疗的机会。该建议将开发装载有荧光染料的血影红细胞作为治疗诊断剂，以通过荧光成像癌细胞并诱导光热杀伤损伤。红细胞将用抗体功能化以在异种移植小鼠模型中体内靶向肿瘤。PI在他的实验室里有许多代表性不足的学生。工作的各个方面将被纳入一个新的类。

PI: Anvari, BahmanProposal No.: 1509218The unique contribution of this proposed work is the ability to engineer nanoparticles that can be made using the patient's own erythrocytes to extend the circulation time and minimize biocompatibility issues so that these nanoparticles can interact with tumors. Light energy can then be used with the nanoparticles to generate heat and provide localized hyperthermia at the tumor to destroy it or augment chemo or radiotherapy. Personalized medicine has great potential and this work can make important contributions to this field.Effective treatment with a minimum of side effects of various malignant tumors remains an important problem in modern medicine. Personalized medicine gives the opportunity to direct and optimize such treatment to individual patients based upon their genetic and immunological makeup. This proposal will develop ghost erythrocytes loaded with fluorescent dyes as theranostic agents to image cancer cells by fluorescence and also to induce photothermal killing damage. The erythrocytes will be functionalized with an antibody to target tumors in vivo in xenograft mouse models. The PI has had many under-represented students in his lab. Aspects of the work will be incorporated into a new class.