SGER: The Sensitivity of XANES Spectroscopy to Protein Folding

SGER：XANES 光谱对蛋白质折叠的敏感性

• 批准号: 0523905
• 负责人: Pupa Gilbert
• 金额: $ 5万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0523905&HistoricalAwards=false
• 关键词: SGER; Sensitivity; XANES; Spectroscopy; Protein

This SGER award provides funding for a series of preliminary experiments to demonstrate that X-ray Absorption Near-Edge Structure (XANES) spectroscopy has the potential to be used as a technique for observing changes in structure as proteins fold. These test experiments, conducted under different protein environments, should confirm whether an earlier observation that this is the case can be conclusively proven. If so, then XANES spectroscopy could potentially become a powerful tool in the experimental study of protein folding and have a broad impact across many areas of biological physics.

该SGER奖为一系列初步实验提供资金，以证明x射线吸收近边缘结构（XANES）光谱有可能被用作观察蛋白质折叠时结构变化的技术。这些在不同蛋白质环境下进行的测试实验，应该可以证实早期的观察是否可以得到确凿的证明。如果是这样，那么XANES光谱可能会成为蛋白质折叠实验研究的有力工具，并在生物物理学的许多领域产生广泛的影响。