SGER: The Sensitivity of XANES Spectroscopy to Protein Folding, Misfoding and Aggregation

SGER：XANES 光谱对蛋白质折叠、错误折叠和聚集的敏感性

• 批准号: 0646018
• 负责人: Pupa Gilbert
• 金额: $ 5万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0646018&HistoricalAwards=false
• 关键词: SGER; Sensitivity; XANES; Spectroscopy; Protein

This SGER provides support for the postdoctoral research activities of an associate of the PI to conduct several experiments designed to explore the potential for the use of x-ray absorption near-edge structure (XANES) in the study of protein misfolding and aggregation. The team will pursue two directions, an analysis of crystalline versus non-crystalline proteins and alpha-helical versus beta-pleated conformations in dissimilar proteins.

该SGER为PI助理的博士后研究活动提供支持，以进行多项实验，旨在探索X射线吸收近边结构（XANES）在蛋白质错误折叠和聚集研究中使用的潜力。 该团队将追求两个方向，分析晶体与非晶体蛋白质和不同蛋白质中的α-螺旋与β-折叠构象。