Statistische Physik der Transkription und ihrer Regulierung

转录及其调控的统计物理

• 批准号: 17321752
• 负责人: Professor Dr. Stefan Klumpp
• 金额: --
• 依托单位: Institut für Dynamik komplexer Systeme
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/17321752?language=en
• 关键词: Statistische; Physik; der; Transkription; und

Transcription is the first step in gene expression. It is tightly controlled both during the recruitment of RNA polymerases to the DNA, and during their movement along the DNA. The second type of control is the subject of this project where it is studied theoretically using methods from statistical physics. We have introduced a stochastic model for the complex dynamics of the RNA polymerase movement – and for the traffic of many polymerases on the same DNA template, because interactions of RNA polymerases play an important role – which we will use to develop a quantitative theoretical description of the control mechanisms which act on the traffic of RNA polymerases. So far, such a quantitative description is only available for the control of the initiation of transcription, but not for control during later stages. In addition, we will model how the concentration and activity of the transcription machinery itself is controlled as part of the control of cellular growth.

转录是基因表达的第一步。它在RNA聚合酶向DNA募集期间以及在它们沿DNA移动的过程中都受到严格的控制。第二种类型的控制是本项目的主题，在该项目中，使用统计物理的方法对其进行理论研究。我们为RNA聚合酶运动的复杂动力学引入了一个随机模型--以及同一DNA模板上多个聚合酶的流量，因为RNA聚合酶的相互作用起着重要作用--我们将使用该模型来开发对RNA聚合酶流量起作用的控制机制的定量理论描述。到目前为止，这样的定量描述只适用于转录起始的控制，而不适用于后期阶段的控制。此外，我们将模拟转录机器本身的浓度和活性是如何被控制的，作为控制细胞生长的一部分。