Statistische Physik der Transkription und ihrer Regulierung

转录是基因表达的第一步。它在RNA聚合酶向DNA的募集过程中以及它们沿DNA沿着运动的过程中都受到严格控制。第二类控制是本项目的主题，它是从统计物理学的方法进行理论研究。我们已经介绍了一个随机模型的复杂动力学的RNA聚合酶的运动-和交通的许多聚合酶在同一个DNA模板，因为RNA聚合酶的相互作用起着重要的作用-我们将使用它来开发一个定量的理论描述的控制机制，作用于交通的RNA聚合酶。到目前为止，这种定量描述仅可用于控制转录的起始，而不能用于后期阶段的控制。此外，我们将模拟转录机制本身的浓度和活性是如何控制的，作为细胞生长控制的一部分。

Transcription is the first step in gene expression. It is tightly controlled both during the recruitment of RNA polymerases to the DNA, and during their movement along the DNA. The second type of control is the subject of this project where it is studied theoretically using methods from statistical physics. We have introduced a stochastic model for the complex dynamics of the RNA polymerase movement – and for the traffic of many polymerases on the same DNA template, because interactions of RNA polymerases play an important role – which we will use to develop a quantitative theoretical description of the control mechanisms which act on the traffic of RNA polymerases. So far, such a quantitative description is only available for the control of the initiation of transcription, but not for control during later stages. In addition, we will model how the concentration and activity of the transcription machinery itself is controlled as part of the control of cellular growth.