CAA: Identification of Genetic Networks in Neurospora Crassa: A Systems Biology Approach

CAA：粗糙脉孢菌遗传网络的鉴定：系统生物学方法

• 批准号: 0542915
• 负责人: David Logan
• 金额: $ 15.71万
• 依托单位: Clark Atlanta University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0542915&HistoricalAwards=false
• 关键词: CAA; Identification; Genetic; Networks; Neurospora

The primary objective of this research is to provide a clearer view of metabolic networks in living organisms. The research will be focused on the metabolism of quinic acid in the bread mold Neurospora crassa. The mold's metabolic behavior will be examined during a change from sucrose, which is a favorable nutrient, to quinic acid, a less desirable nutrient. The metabolic response of the mold will be monitored by measuring the organism's messenger ribonucleic acid levels by using molecular and computational biology methods. Altogether, the information produced in this research will provide the basis for the identification of currently described metabolic networks and reveal new interacting networks in living organisms.There are many unanswered questions about the regulation of an organism's metabolic network. In addition, the connection between a specific network and the entire metabolic network in living things is not firmly established. The approach in this project will expand the knowledge of metabolic regulation in the bread mold N. crassa to include many organisms. The information revealed in this research will provide more knowledge of what makes a living thing function and establish a foundation for future investigations on the metabolic behavior of life. The impact on the education of underrepresented students is clear as this project will provide excellent training and mentoring for young scientists and assist them in making career choices in the field of biology and other scientific disciplines.

这项研究的主要目的是提供对生物体代谢网络的更清晰的了解。该研究将重点关注面包霉菌粗糙脉孢菌中奎宁酸的代谢。 在从蔗糖（一种有利的营养物质）转变为奎尼酸（一种不太理想的营养物质）的过程中，将检查霉菌的代谢行为。将通过使用分子和计算生物学方法测量生物体的信使核糖核酸水平来监测霉菌的代谢反应。 总而言之，本研究产生的信息将为识别当前描述的代谢网络提供基础，并揭示生物体中新的相互作用网络。关于生物体代谢网络的调节，还有许多悬而未决的问题。 此外，生物体内的特定网络与整个代谢网络之间的联系并不牢固。 该项目的方法将扩展面包霉菌粗糙链孢菌代谢调节的知识，以涵盖许多生物体。 这项研究揭示的信息将提供更多有关生物发挥功能的知识，并为未来生命代谢行为的研究奠定基础。 对代表性不足的学生的教育的影响是显而易见的，因为该项目将为年轻科学家提供良好的培训和指导，并帮助他们在生物学和其他科学学科领域做出职业选择。