Competitive and Coevolutionary Dynamics of Antibiotic Interactions Within Streptomyces Communities in Soil

产生抗生素的细菌在土壤中无处不在，但抗生素相互作用对微生物群落生态和进化的意义尚不清楚。特别是，关于土壤微生物之间不同类型的相互作用(抑制、抗生素诱导、互惠或利用)的频率，或具有不同抑制表型的土壤微生物的适合性的信息很少。这项研究将开发分子工具和定量模型，用于探索抗生素抑制相互作用对土壤微生物群落动力学的意义。土壤微生物仍然是重要的医学抗生素的重要来源，并被认为包含了世界上大多数未开发的生物多样性。对该项目的研究将提供对加强我们对土壤微生物多样性和动态的了解至关重要的工具和信息。此外，该项目将支持本科生和研究生以及一名博士后科学家的教育，并将支持与多个小型学院的女性合作者继续保持合作关系。

Antibiotic-producing bacteria are ubiquitous in soils, but the significance of antibiotic interactions to microbial community ecology and evolution is not well understood. In particular, there is little information on the frequency of different types of interactions (inhibitory, antibiotic induction, mutualistic, or exploitative) among microbes in soil, or on the fitness of soil microbes possessing distinct inhibitory phenotypes. This research will develop molecular tools and quantitative models for use in exploring the significance of antibiotic inhibitory interactions to microbial community dynamics in soil. Soil microbes remain a significant source of medically important antibiotics, and are believed to contain the majority of the worlds unexplored biotic diversity. Research on this project will provide tools and information critical to enhancing our understanding of the diversity and dynamics of soil microbes. In addition, this project will support the education of undergraduate and graduate students as well as a post-doctoral scientist, and will support continued collaborative relationships with female collaborators at multiple small colleges.