Competitive and Coevolutionary Dynamics of Antibiotic Interactions Within Streptomyces Communities in Soil

土壤中链霉菌群落内抗生素相互作用的竞争和共同进化动力学

• 批准号: 0543213
• 负责人: Linda Kinkel
• 金额: $ 9万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0543213&HistoricalAwards=false
• 关键词: Competitive; Coevolutionary; Dynamics; Antibiotic; Interactions

Antibiotic-producing bacteria are ubiquitous in soils, but the significance of antibiotic interactions to microbial community ecology and evolution is not well understood. In particular, there is little information on the frequency of different types of interactions (inhibitory, antibiotic induction, mutualistic, or exploitative) among microbes in soil, or on the fitness of soil microbes possessing distinct inhibitory phenotypes. This research will develop molecular tools and quantitative models for use in exploring the significance of antibiotic inhibitory interactions to microbial community dynamics in soil. Soil microbes remain a significant source of medically important antibiotics, and are believed to contain the majority of the worlds unexplored biotic diversity. Research on this project will provide tools and information critical to enhancing our understanding of the diversity and dynamics of soil microbes. In addition, this project will support the education of undergraduate and graduate students as well as a post-doctoral scientist, and will support continued collaborative relationships with female collaborators at multiple small colleges.

产生抗生素的细菌在土壤中无处不在，但是抗生素相互作用对微生物群落生态学和进化的意义尚不清楚。 特别是，关于土壤中微生物中不同类型相互作用（抑制性，抗生素诱导，互动或剥削性）的频率的信息很少，或者涉及具有独特的抑制表型的土壤微生物的适应性。 这项研究将开发分子工具和定量模型，以探索抗生素抑制性相互作用对土壤中微生物群落动态的重要性。 土壤微生物仍然是医学上重要的抗生素的重要来源，据信含有大多数世界未开发的生物多样性。 对该项目的研究将为我们增强我们对土壤微生物多样性和动态的理解至关重要的工具和信息。 此外，该项目将支持本科生和研究生的教育以及博士后科学家，并将支持与多个小学院的女性合作者的持续合作关系。