Data Analysis Environment for Microbial Proteome Studies

BIATECH非营利研究中心获得了一笔赠款，用于开发一个可定制的，易于使用的，强大的数据库和数据分析软件环境的原型，用于分析微生物蛋白质组。同时开发统计模型和分析软件，同时应用于新的生物学数据，比孤立的活动更可取，因为这些领域之间的反馈程度很高。研究人员将与多种微生物合作，实现快速的开发和测试周期，对物种间的差异具有鲁棒性，从而为更广泛的科学界提供工具。研究人员将记录动态生物体状态和环境数据，并将其纳入分析，为进一步发现提供丰富的潜力。研究人员将免费向更广泛的科学界提供可用的数据库模式，软件和统计模型，以及将这些应用于三种微生物分析的结果。为了鼓励社区使用本研究的产品，研究人员将开发一个特殊的暑期项目，以指导本科生和研究生，博士后研究员和研究人员，从合作实验室开始。该暑期项目的参与者将学习，测试和应用所提出的开发和创新的完整周期到他们感兴趣的生物体，目的是使他们能够在自己的实验室部署工具和技术。此外，BIATECH将为该地区公立学校的高中生举办科学课程，优先考虑有风险和贫困的青年。这些学生将获得如何通过动手样品制备，质谱实验和计算分析操作的真实的科学实验室的第一手经验。

BIATECH Nonprofit Research Center is awarded a grant to develop a prototype of a customizable, easy-to-use, and robust database and data analysis software environment for analyzing microbial proteomes. Simultaneous development of statistical models and analysis software, with concurrent application to new biological data, is preferable to isolated activity because of the high degree of feedback between these domains. The investigators will work with multiple microorganisms, enabling a rapid development and testing cycle that is robust to differences across species, resulting in tools that are readily available to the broader scientific community. The investigators will record dynamic organism state and environment data and incorporate these into the analysis, providing a rich potential for further discovery. The investigators will freely provide the broader scientific community with usable database schema, software, and statistical models, and the results of applying these to the analysis of the three microorganisms. To encourage community use of the products of this research, the investigators will develop a special Summer Program to instruct undergraduate and graduate students, postdoctoral fellows, and research staff, beginning with those of the collaborating laboratories. The participants of this Summer Program will learn, test, and apply the complete cycle of the proposed developments and innovations to their organisms of interest, with the aim of enabling them to deploy the tools and techniques at their own labs. Additionally, BIATECH will host science courses for high school students from public schools in the area, with priority given to at-risk and underprivileged youth. These students will gain first-hand experience of how a real scientific lab operates through hands-on sample preparation, mass spectrometry experimentation, and computational analysis.