SGER: Gold Standard Set for Functional Annotation of Microbial Hypothetical Proteins

SGER：微生物假设蛋白质功能注释的黄金标准集

• 批准号: 0748739
• 负责人: Eugene Kolker
• 金额: $ 17.98万
• 依托单位: Seattle Children's Hospital
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0748739&HistoricalAwards=false
• 关键词: SGER; Gold; Standard; Set; Functional

This Small Grant for Exploratory Research (SGER) will create a large gold standard reference set of newly annotated diverse genes that were previously designated as hypothetical (having unknown function). This set will serve as a baseline for validation and comparative analysis of prospective approaches to functional annotation of uncharacterized genes. This reference set is aimed at overcoming one of the major bottlenecks of microbiology and modern biology in general, and microbial genome sequencing in particular. Hypothetical (uncharacterized) genes constitute approximately one third of all predicted genes and their number is expanding rapidly with each new genome sequencing project. New computational approaches to gene annotation are being developed almost daily to address the hurdle of currently having 70% or less of each genome assigned with known function. This research will result in a reference set of 200 previously hypothetical genes with high quality functional annotation. This set will serve as a valuable resource for the development and validation of new methods for the function annotation of new and existing genomes. It will also serve as a benchmark for existing annotation methods and databases.

这项探索性研究小额资助（SGER）将创建一个新注释的多样性基因的大型金标准参考集，这些基因以前被指定为假设（具有未知功能）。这组将作为一个基线的验证和比较分析的前瞻性方法的功能注释的未表征的基因。该参考集旨在克服微生物学和现代生物学的主要瓶颈之一，特别是微生物基因组测序。假设（未表征）基因约占所有预测基因的三分之一，其数量随着每个新的基因组测序计划迅速扩大。几乎每天都在开发新的基因注释计算方法，以解决目前每个基因组的70%或更少分配有已知功能的障碍。 这项研究将产生一个参考集的200个以前假设的基因与高质量的功能注释。这一套将作为一个宝贵的资源，为新的和现有的基因组功能注释的新方法的开发和验证。它还将作为现有注释方法和数据库的基准。