CAREER: Metal-Organic Frameworks from Dipyrrin Metalloligands

这个无机、生物无机和有机金属化学项目的奖项支持加州大学圣地亚哥分校的Seth Cohen博士使用异位螯合剂制备新的金属配体，用于构建功能化金属有机框架（mof）。为了描述可预测网络形成所需的基本设计原则，将研究金属配体复制已知MOF结构的能力。初步研究表明，金属配位体可以通过一些连接基序成功地再现目标mof的拓扑结构。早期的研究结果还表明，可以利用八面体三（螯合）构建块的手性制备同手性mof。此外，客体交换研究表明，这些mof是坚固的，可以很容易地交换被封装的物种。研究将进行调查不同的对称性和连接基序的金属配体，以及由此产生的框架的主客体性质。最终，该研究计划旨在揭示产生所需MOF拓扑所需的金属寡配体的基本设计参数。阐明这些中心参数将允许合理修改配合物，以用作具有可预测结构的功能化mof的构建块。具有纳米级孔隙和通道的材料将被设计和合成。这些材料可能会在快速发展的纳米技术领域得到广泛应用，在燃料电池、催化剂和传感器中发挥核心作用。利用对法医学学科日益增长的兴趣，法医学主题将被纳入化学入门课程，作为激发和吸引学生早期学术生涯的一种手段。来自当地法医实验室的演讲嘉宾将说明在普通化学课程中提出的概念的适用性。加州大学圣地亚哥分校和美国缉毒局西南实验室启动了一个合作项目，将为本科生提供一个学习基本化学原理和方法在工作中的应用的机会。这个合作项目通过为本科生提供真实的化学工作经验，使学术机构和政府机构受益，同时将当地DEA实验室与未来法医化学家的潜在来源联系起来，他们对工作要求有很好的工作知识。其他教育目标包括拓展和联络那些在科学领域未被充分代表的少数民族的校园，以及主要本科院校的教育工作者的休假访问。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports Dr. Seth Cohen at the University of California at San Diego to use heteroditopic chelators to prepare new metalloligands for the construction of functionalized metal-organic frameworks (MOFs). The ability of metalloligands to replicate known MOF architectures will be examined in order to delineate fundamental design principles required for predictable network formation. Preliminary studies show that with some linking motifs, metalloligands can successfully reproduce the topology of target MOFs. Early findings also show that homochiral MOFs can be prepared that exploit the chirality of an octahedral tris(chelate) building block. Furthermore, guest exchange studies show that these MOFs are robust and can readily exchange encapsulated species. Studies will be undertaken to investigate metalloligands of different symmetries and linking motifs, as well as the host-guest properties of the resultant frameworks. Ultimately, this research program seeks to reveal the essential design parameters for a metalloligand needed to generate a desired MOF topology. Elucidating these central parameters will allow for the rational modification of coordination complexes for use as building blocks in functionalized MOFs with a predictable structure.Materials that possess nanoscale pores and channels will be designed and synthesized. Such materials may find a host of applications in the rapidly growing field of nanotechnology, where they may play central roles in fuel cells, catalysts, and sensors. Capitalizing on the increased interest in the subject of forensic sciences, forensic themes will be incorporated into introductory chemistry courses as a means to excite and engage students early in their academic career. Guest speakers from local forensic laboratories will illustrate the applicability of the concepts being presented in general chemistry courses. The commencement of a co-op program between U.C. San Diego and the Southwest Laboratory of the Drug Enforcement Administration will give undergraduate students an opportunity to learn about on-the-job applications of fundamental chemical principles and methods. This co-op program benefits both the academic and government institutions by providing a real chemistry work experience to the undergraduate participants, while simultaneously connecting the local DEA laboratory to a potential source of future forensic chemists, who have an excellent working knowledge of the job requirements. Other educational goals include outreach and liaison efforts to campuses with significant populations of underrepresented minorities in science, and sabbatical visits for educators from primarily undergraduate institutions.