CAREER: Metal-Organic Frameworks from Dipyrrin Metalloligands

职业：二吡啉金属配体的金属有机框架

• 批准号: 0546531
• 负责人: Seth Cohen
• 金额: $ 56万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0546531&HistoricalAwards=false
• 关键词: CAREER; Metal; Organic; Frameworks; Dipyrrin

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports Dr. Seth Cohen at the University of California at San Diego to use heteroditopic chelators to prepare new metalloligands for the construction of functionalized metal-organic frameworks (MOFs). The ability of metalloligands to replicate known MOF architectures will be examined in order to delineate fundamental design principles required for predictable network formation. Preliminary studies show that with some linking motifs, metalloligands can successfully reproduce the topology of target MOFs. Early findings also show that homochiral MOFs can be prepared that exploit the chirality of an octahedral tris(chelate) building block. Furthermore, guest exchange studies show that these MOFs are robust and can readily exchange encapsulated species. Studies will be undertaken to investigate metalloligands of different symmetries and linking motifs, as well as the host-guest properties of the resultant frameworks. Ultimately, this research program seeks to reveal the essential design parameters for a metalloligand needed to generate a desired MOF topology. Elucidating these central parameters will allow for the rational modification of coordination complexes for use as building blocks in functionalized MOFs with a predictable structure.Materials that possess nanoscale pores and channels will be designed and synthesized. Such materials may find a host of applications in the rapidly growing field of nanotechnology, where they may play central roles in fuel cells, catalysts, and sensors. Capitalizing on the increased interest in the subject of forensic sciences, forensic themes will be incorporated into introductory chemistry courses as a means to excite and engage students early in their academic career. Guest speakers from local forensic laboratories will illustrate the applicability of the concepts being presented in general chemistry courses. The commencement of a co-op program between U.C. San Diego and the Southwest Laboratory of the Drug Enforcement Administration will give undergraduate students an opportunity to learn about on-the-job applications of fundamental chemical principles and methods. This co-op program benefits both the academic and government institutions by providing a real chemistry work experience to the undergraduate participants, while simultaneously connecting the local DEA laboratory to a potential source of future forensic chemists, who have an excellent working knowledge of the job requirements. Other educational goals include outreach and liaison efforts to campuses with significant populations of underrepresented minorities in science, and sabbatical visits for educators from primarily undergraduate institutions.

该无机、生物无机和有机金属化学项目奖项支持加州大学圣地亚哥分校的 Seth Cohen 博士使用异二位螯合剂制备新的金属配体，用于构建功能化金属有机框架 (MOF)。 将检查金属配体复制已知 MOF 结构的能力，以描绘可预测网络形成所需的基本设计原则。 初步研究表明，通过一些连接基序，金属配体可以成功地再现目标MOF的拓扑结构。 早期研究结果还表明，可以利用八面体三（螯合物）结构单元的手性来制备同手性 MOF。 此外，客体交换研究表明，这些 MOF 非常坚固，并且可以轻松交换封装的物质。 将进行研究以调查不同对称性和连接基序的金属配体，以及所得框架的主客体特性。 最终，该研究项目旨在揭示生成所需 MOF 拓扑所需的金属配体的基本设计参数。 阐明这些中心参数将允许对配位络合物进行合理修饰，以用作具有可预测结构的功能化 MOF 的构建块。将设计和合成具有纳米级孔和通道的材料。 此类材料可能会在快速发展的纳米技术领域得到广泛应用，在燃料电池、催化剂和传感器中发挥核心作用。 利用人们对法医学学科日益增长的兴趣，法医学主题将被纳入化学入门课程，作为在学术生涯早期激发和吸引学生的一种手段。 来自当地法医实验室的演讲嘉宾将说明普通化学课程中所介绍概念的适用性。 U.C. 之间合作项目的开始圣地亚哥和缉毒局西南实验室将为本科生提供学习基本化学原理和方法在工作中应用的机会。 该合作项目通过为本科生参与者提供真正的化学工作经验，同时将当地 DEA 实验室与未来法证化学家的潜在来源联系起来，使学术和政府机构受益，这些化学家对工作要求拥有出色的工作知识。 其他教育目标包括对科学领域存在大量代表性不足的少数群体的校园进行外展和联络工作，以及对主要是本科院校的教育工作者进行休假访问。