New Ligands, Late Transition Metal Photochemistry, and DNA

新配体、后过渡金属光化学和 DNA

• 批准号: 0550241
• 负责人: David McMillin
• 金额: --
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2010-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0550241&HistoricalAwards=false
• 关键词: New; Ligands; Late; Transition; Metal

With the support of the Inorganic, Bioinorganic and Organometallic Chemistry Program, Professor David R. McMillin, of the Department of Chemistry at Purdue University proposes the development of synthetic methods to form new cationic porphyrin ligands that are optimized to intercalate into B-form DNA without steric strain. These porphyrins and their platinum complexes will serve as chromophoric and emissive probes for binding studies where the steric, electronic and coulombic forces of DNA binding interactions are studied in the ground and excited states via absorption and emission spectroscopies as well as circular dichroism studies. Competitive binding studies will identify systems selective for DNA hairpins and quadruplexes while exploitation of the novel emission quenching mechanisms will yield important information about the adducts formed. This grant will provide a deeper understanding of host-guest interactions using novel, rationally derived metalloporphyrins. Professor McMillin contributes to the recruitment of underrepresented minorities through his work as a Visiting Research Fellow in South Africa. Several student researchers from South Africa have joined his research group, enhancing the international experience of U.S. students.

在无机，生物无机和有机化学计划的支持下，教授大卫R。普渡大学化学系的McMillin提出了合成方法的发展，以形成新的阳离子卟啉配体，这些配体被优化以插入B型DNA而没有空间应变。 这些卟啉和它们的铂络合物将作为发色和发射探针的结合研究中的空间，电子和库仑力的DNA结合相互作用的研究，通过吸收和发射光谱以及圆二色性研究在基态和激发态。 竞争性结合的研究将确定系统的选择性DNA发夹和四链体，而开发的新的发射猝灭机制将产生重要的信息所形成的加合物。 这项资助将提供一个更深入的了解主客体相互作用，使用新的，合理衍生的金属卟啉。 麦克米伦教授通过他在南非担任访问研究员的工作，为招聘代表性不足的少数民族做出了贡献。 来自南非的几名学生研究人员加入了他的研究小组，增强了美国学生的国际经验。