Late Transition Metal Photochemistry

后过渡金属光化学

• 批准号: 9726435
• 负责人: David McMillin
• 金额: $ 32.9万
• 依托单位: Purdue Research Foundation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9726435&HistoricalAwards=false
• 关键词: Late; Transition; Metal; Photochemistry

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research in inorganic photochemistry by Dr. David R. McMillin, Chemistry Department, Purdue University. A major objective is to use luminescent probes to gain insight into the requirements for intercalation of transition metal complexes into DNA. Various subsituents will be added to Cu(II) porphyrins in order to tailor the excited state lifetimes and oxidizing abilities of these luminescent, charge transfer compounds. The interaction of the copper compounds with hairpin-forming oligonucleotides will provide information on base and sequence dependence of DNA-binding interactions. Pt(II) terpyridines that are very sensitive to electronic changes will be used to identify factors affecting excited-state decay processes and to distinguish two types of adduct formation--intercalation and covalent bonding--with form-B DNA. The charge-transfer excited state of the intercalated complex is quenched by guanine, so the experiments will also provide indications of possible nuclease activity. Transition metal complexes can insert into a helical DNA strand disrupting its structure and reactivity and can break the strand itself. Controlling the binding of these complexs so that disruption or cleavage occurs at particular sites on the DNA chain has important pharmaceutical implications. In this research, luminescent probes will be developed to identify the type and location of metal complex binding to DNA or DNA-like proteins. This research also has some relevance to the development of temperature-sensitive luminescent paints.

普渡大学化学系David R.McMillin博士在无机、生物无机化学和金属有机化学项目中获得该奖项，以支持其在无机光化学方面的研究。一个主要的目标是使用发光探针来洞察过渡金属络合物嵌入DNA的要求。为了调整这些发光的电荷转移化合物的激发态寿命和氧化能力，将在铜(II)卟啉中添加各种取代物。铜化合物与发夹状寡核苷酸的相互作用将提供DNA结合相互作用的碱基和序列依赖性的信息。对电子变化非常敏感的PT(II)联吡啶将被用来确定影响激发态衰变过程的因素，并区分两种类型的加合物形成--插层和共价键-与B型DNA。插层络合物的电荷转移激发态被鸟嘌呤猝灭，因此实验还将提供可能的核酸酶活性的指示。过渡金属络合物可以插入到螺旋DNA链中，破坏其结构和反应能力，并可以破坏链本身。控制这些复合体的结合，使其在DNA链上的特定位置发生破坏或切割，具有重要的药学意义。在这项研究中，将开发发光探针来识别与DNA或DNA样蛋白结合的金属络合物的类型和位置。本研究对温敏发光涂料的发展也有一定的借鉴意义。