Photochemistry with Late Transition Metal Complexes

后过渡金属配合物的光化学

• 批准号: 0108902
• 负责人: David McMillin
• 金额: $ 31.5万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0108902&HistoricalAwards=false
• 关键词: Photochemistry; Late; Transition; Metal; Complexes

David McMillan of Purdue University is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program to conduct research on photochemistry of complexes of late transition elements and DNA. The proposed research will use photochemical methods to gain understanding of binding of late transition metal porphyrin complexes to DNA and to devise methods to direct that binding. The research will also develop porphyrin and polypyridine complexes of late transition series elements as novel photosensitive probes for technologically important uses. Many late transition series complexes feature open coordination positions. The chemical flexibility engendered by such vacancies can be exploited to gain otherwise unattainable understanding of interactions between metallic species and DNA. Photochemical processes involving complexes of late transition metals with DNA have considerable potential for producing new agents for photodynamic therapy, as well as in clarifying factors influencing the binding of metallic species to DNA.

普渡大学的David McMillan在无机、生物无机和有机金属化学项目的支持下，对后期过渡元素和DNA络合物的光化学进行研究。提出的研究将使用光化学方法来了解晚期过渡金属卟啉配合物与DNA的结合，并设计指导这种结合的方法。该研究还将开发卟啉和多吡啶的晚过渡系列元素配合物，作为技术上重要用途的新型光敏探针。许多后期过渡系列复合物具有开放的配位。利用这种空位所产生的化学柔韧性，可以获得对金属物种和DNA之间相互作用的其他无法达到的理解。涉及晚期过渡金属与DNA络合物的光化学过程具有相当大的潜力，可用于生产光动力治疗的新药剂，以及澄清影响金属物种与DNA结合的因素。