课题基金 / 基金详情

New Light on Late Transition Metal Complexes

New Light on Late Transition Metal Complexes
后过渡金属配合物的新进展
批准号:
9401238
负责人:
David McMillin
金额:
$31.5万
依托单位:
依托单位国家:
美国
项目类别:
Continuing Grant
财政年份:
1994
资助国家:
美国
项目状态:
已结题
起止时间:
1994-07-15 至 1998-06-30

项目摘要

项目成果

David McMillin的其他基金

相似基金

相关文献

中文摘要
翻译
本项目隶属于无机、生物无机和有机金属化学专业,旨在阐明铂(II)和铜(II)四配位配合物的方形平面激发态弛豫机制。这项工作是基于早期的观察,即这些化合物的激发态的寿命强烈地受到配合物与其环境的二次相互作用的影响。因此,它们具有作为分子探针和传感器的潜力。具体的研究将包括铂(II)三联吡啶和铜(II)卟啉配合物在流体介质和嵌入DNA中的光化学表征,并尝试通过取代对三联吡啶配体进行修饰来增加前者配合物的激发态寿命。将采用的技术包括发光、吸收和CD光谱,以及猝灭反应和温度相关测量。电磁辐射的吸收产生激发态,这些激发态可以通过非辐射(产生热量)或辐射(发射光)途径恢复(松弛)到基态。通过对辐照弛豫化合物发射光谱的研究,可以获得有关其电子结构的大量信息。辐射弛豫可以高度依赖于分子所处的环境,在有利的情况下,对发射光谱的观察可以用作分子环境的探针。这个项目的主要目标是更好地理解某些过渡金属化合物的激发态弛豫发生的方式,以及这些是如何由分子环境决定的。在许多领域有许多潜在的应用,包括光传感器、光动力癌症治疗和分子电子学。
英文摘要
This project, in the Inorganic, Bioinorganic, and Organometallic Chemistry Program, is concerned with elucidation of the mechanisms of excited state relaxation in square planar, four- coordinate complexes of platinum(II) and copper(II). The work is based upon earlier observations that the lifetimes of excited states of such compounds are strongly affected by secondary interactions of the complexes with their environments. As a result they have potential as molecular probes and sensors. Specific studies will include characterization of the photochemistry of platinum(II) terpyridine and copper(II) porphyrin complexes both in fluid media and intercalated into DNA, and attempts to increase the excited state lifetimes of the former complexes by modification of the terpyridine ligand through substitution. Techniques to be employed will include luminescence, absorption and CD spectroscopies in conjunction with quenching reactions and temperature dependent measurements. Absorption of electromagnetic radiation generates excited electronic states that may revert (relax) to the ground state by non-irradiative (heat generating) or irradiative (emission of light) pathways. A great deal of information can be obtained about the electronic structure of compounds that undergo irradiative relaxation by studies of their emission spectra. Irradiative relaxation can be highly dependent upon the environment in which the molecule resides and under favorable circumstances the observation of an emission spectrum can be used as a probe of the molecular environment. This project has as its major objective the development of a better understanding of the ways in which relaxation of excited states of certain transition metal compounds occur and how these are determined by the molecular environment. There are many potential applications in a number of areas including photosensors, photodynamic cancer therapy, and molecular electronics.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Late Transition Metal Lumiphores and Probes
  • 批准号:
    0847229
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $39.0万
  • 财政年份:
    2009
  • 负责人:
    David McMillin
  • 依托单位:
New Ligands, Late Transition Metal Photochemistry, and DNA
  • 批准号:
    0550241
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $0.0万
  • 财政年份:
    2006
  • 负责人:
    David McMillin
  • 依托单位:
Photochemistry with Late Transition Metal Complexes
  • 批准号:
    0108902
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $31.5万
  • 财政年份:
    2001
  • 负责人:
    David McMillin
  • 依托单位:
Late Transition Metal Photochemistry
  • 批准号:
    9726435
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $32.9万
  • 财政年份:
    1998
  • 负责人:
    David McMillin
  • 依托单位:
国内基金
海外基金
上调间充质干细胞LIGHT、IL-21及 Sig lec-10用于卵巢癌免疫协同增效治疗 的多模态影像学研究
  • 批准号:
  • 项目类别:
    省市级项目
  • 资助金额:
    10.0万元
  • 批准年份:
    2025
  • 负责人:
    曹明慧
  • 依托单位:
LIGHT/HVEM-亮氨酸轴异常引起蜕膜基质细胞过度衰老致复发流产的机制研究
  • 批准号:
    32370914
  • 项目类别:
    面上项目
  • 资助金额:
    50万元
  • 批准年份:
    2023
  • 负责人:
    李明清
  • 依托单位:
LIGHT促NLRP3炎症小体活化介导他克莫司所致肾纤维化的作用机制研究
  • 批准号:
    82300855
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    30万元
  • 批准年份:
    2023
  • 负责人:
    唐铭
  • 依托单位:
LIGHT-HVEM通路提升CAR-T细胞抗肿瘤活性的机制研究