Quadrupolar MRI Contrast in Soft Matter Systems

软物质系统中的四极 MRI 对比

• 批准号: 0554400
• 负责人: Alexej Jerschow
• 金额: --
• 依托单位: New York University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0554400&HistoricalAwards=false
• 关键词: Quadrupolar; MRI; Contrast; Soft; Matter

In this award to New York University, funded by the Experimental Physical Chemistry Program of the Chemistry Division, Prof. Alexej Jerschow of the Chemistry Department and his graduate research students will work to develop new magnetic resonance methods for enhancing magnetic resonance imaging (MRI) contrast of quadrupolar nuclei in soft condensed matter systems. The initial studies will focus on sodium-23 nuclei in model soft matter systems as well as in cartilage tissues. The ultimate goal of this research is to develop general magnetic resonance imaging methods that can be used with other half-integer quadrupolar nuclei. Ultimately, the research may lead to powerful methods that could be used in magnetic resonance imaging of metal-binding to DNA/RNA and proteins, tumor detection in tissues, quality control of food and materials, and void-space imaging. Besides the broader technological, scientific and societal impacts of the research being supported, the research students working on these projects will be trained in the development of cutting-edge nuclear magnetic resonance methods. In addition, Prof. Jerschow plans to continue his collaboration with Dr. Eleonora Del Federico from the Pratt Institute on nuclear magnetic resonance of art pigments. Prof. Jerschow will also continue his mentoring of undergraduate students and high-school teachers.

该奖项由纽约大学化学系实验物理化学计划资助，化学系的Alexej Jerschow教授及其研究生将致力于开发新的磁共振方法，以增强软凝聚态系统中四极核的磁共振成像（MRI）对比度。 最初的研究将集中在模型软物质系统以及软骨组织中的钠-23核。 本研究的最终目标是开发可用于其他半整数四极核的通用磁共振成像方法。 最终，这项研究可能会产生强大的方法，可用于金属与DNA/RNA和蛋白质结合的磁共振成像，组织中的肿瘤检测，食品和材料的质量控制以及空隙空间成像。 除了支持研究的更广泛的技术，科学和社会影响外，参与这些项目的研究生将接受尖端核磁共振方法开发的培训。 此外，Jerschow教授计划继续与普拉特研究所的Eleonora Del Federico博士在艺术颜料的核磁共振方面进行合作。 Jerschow教授还将继续指导本科生和高中教师。