Multiscale Mechanical Characterization of Biological Tubes

生物管的多尺度机械表征

• 批准号: 0556362
• 负责人: Michael Sutton
• 金额: --
• 依托单位: University South Carolina Research Foundation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0556362&HistoricalAwards=false
• 关键词: Multiscale; Mechanical; Characterization; Biological; Tubes

The mechanical behavior of soft tissues such as blood vessels is complex and not completely understood. A detailed study of this behavior is important to understand the function of organs such as the heart and blood vessels, which undergo repeated changes in pressure during each heart beat. Many diseases result in changes in both mechanical behavior and microscopic structure of tissues. Thus, understanding how tissue structure, geometry, mechanical properties, and function are related may lead to advances in health care. This project focuses on measuring the structure and mechanical behavior of blood vessels, together with simpler model systems such as collagen tubes. The measured properties will be used to build mathematical models that can predict changes in tissue function resulting from disease. An important part of this work is measuring mechanical properties on the microscopic scale, since the local mechanical environment controls how tissues behave during development and after injury.

血管等软组织的力学行为是复杂的，尚未完全了解。 对这种行为的详细研究对于了解心脏和血管等器官的功能非常重要，这些器官在每次心跳期间都会经历压力的重复变化。 许多疾病导致组织的力学行为和微观结构的变化。 因此，了解组织结构，几何形状，机械性能和功能之间的关系可能会导致医疗保健的进步。 该项目的重点是测量血管的结构和力学行为，以及更简单的模型系统，如胶原蛋白管。测量的特性将用于建立数学模型，可以预测疾病引起的组织功能变化。 这项工作的一个重要组成部分是在微观尺度上测量力学性能，因为局部力学环境控制着组织在发育过程中和损伤后的行为。