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DISSERTATION RESEARCH: The Genetic Basis of Reproductive Isolation Among Two Species of House Mice

论文研究：两种家鼠生殖隔离的遗传基础

基本信息

批准号：
0608452
负责人：
Michael Nachman
金额：
$ 1.17万
依托单位：
University of Arizona
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2006
资助国家：
美国
起止时间：
2006-06-01 至 2008-05-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0608452&HistoricalAwards=false
关键词：
DISSERTATION RESEARCH Genetic Basis Reproductive

项目摘要

Understanding the mechanisms underlying the origin of new species is a fundamental goal of evolutionary biology. In many organisms, the formation of new species depends upon the development of barriers to reproduction. The proposed research will determine the genetic details underlying reproductive barriers between two species of house mice, Mus musculus and Mus domesticus. Previous experiments have shown reproduction between these species produces sterile hybrid males and that some of the genes causing sterility are on the X chromosome. The primary goal of this study is to identify the specific genes on the X chromosome that result in hybrid male sterility. Laboratory breeding experiments will be used to determine which regions of the X chromosome cause hybrid male sterility. Publicly available genome data will be used to identify genes within these regions that are candidates for male sterility. Genetic variation at these genes will be surveyed in natural populations of house mice to determine if they are involved in reproductive isolation in nature.Little is known about the genetic basis of reproductive isolation among most species in nature. Thus, the proposed research offers a unique opportunity to determine the genetic basis of speciation in an important model system and will lay the groundwork for the first time identifying specific genes involved in speciation in a mammal.

了解新物种起源的机制是进化生物学的一个基本目标。在许多生物体中，新物种的形成依赖于繁殖障碍的发展。这项拟议的研究将确定两种家鼠--小鼠和家鼠--之间生殖障碍的遗传细节。之前的实验表明，这些物种之间的繁殖会产生不育的杂交雄性，导致不育的一些基因位于X染色体上。这项研究的主要目标是确定X染色体上导致杂交雄性不育的特定基因。实验室育种实验将用于确定X染色体的哪些区域导致杂交雄性不育。公开的基因组数据将被用来识别这些区域内的男性不育候选基因。这些基因的遗传变异将在家鼠的自然种群中进行调查，以确定它们是否参与了自然界中的生殖隔离。人们对自然界大多数物种生殖隔离的遗传基础知之甚少。因此，拟议的研究为在一个重要的模式系统中确定物种形成的遗传基础提供了一个独特的机会，并将为首次识别哺乳动物中涉及物种形成的特定基因奠定基础。