NER: Self-Assembly of Nanostructures in Functionalized, Hierarchical Zeolite Structures

NER：功能化、分级沸石结构中纳米结构的自组装

• 批准号: 0608977
• 负责人: Sarah Larsen
• 金额: $ 12.97万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0608977&HistoricalAwards=false
• 关键词: NER; Self; Assembly; Nanostructures; Functionalized

The intellectual merit of this project focuses on the functionalization of hollow zeolite structures and the subsequent self-assembly of nanostructures (DNA, gold nanorods) in the hollow zeolite structures. These materials will then be developed for applications in areas such as gene delivery, photonics, catalysis, and optical sensing. The general approach is to prepare and surface derivatize the zeolites with a functional amine group spaced by a cleavable disulfide linkage. The functionalized, nanoporous zeolite tubes will then be utilized as a platform for evaluating gene delivery applications and novel hybrid zeolite-metal building blocks that self-assemble using specific receptor-mediated biological interactions. This highly interdisciplinary project will generate data that establishes the limitations and potential of functionalized, nanoporous zeolites in biological applications. The three main objectives are to: 1) synthesize and selectively functionalize hollow zeolite structures with thiol and amine groups 2) demonstrate the self-assembly of metal nanorods (gold) in the interior of the functionalized zeolite tubes and 3) prepare a gene delivery system based on the self-assembly of plasmid DNA in zeolite structures.The broader impacts of the project include: 1) engaging students from diverse backgrounds in a cross-cutting research program involving chemical engineering, chemistry, materials science, and pharmaceutics, 2) integrating research and education in undergraduate and graduate courses through the development of education materials for undergraduate chemistry courses and interdisciplinary graduate courses and 3) recruiting graduate and undergraduate students from underrepresented groups to participate in the research project.

本项目的智力优势集中在空心沸石结构的功能化以及随后在空心沸石结构中纳米结构（DNA，金纳米棒）的自组装。这些材料将用于基因传递、光子学、催化和光学传感等领域的应用。一般的方法是制备和表面衍生化具有可切割二硫键的功能胺基团的沸石。功能化的纳米多孔沸石管将被用作评估基因传递应用和新型混合沸石-金属构建块的平台，这些混合沸石-金属构建块使用特定受体介导的生物相互作用进行自组装。这个高度跨学科的项目将产生数据，以确定功能化纳米多孔沸石在生物应用中的局限性和潜力。研究的三个主要目标是：1)合成和选择性功能化具有硫醇和胺基的空心沸石结构；2)证明金属纳米棒（金）在功能化沸石管内部的自组装；3)制备基于质粒DNA在沸石结构中自组装的基因传递系统。项目的更广泛影响包括：1)让来自不同背景的学生参与涉及化学工程、化学、材料科学和制药的跨领域研究项目；2)通过开发本科化学课程和跨学科研究生课程的教材，将本科和研究生课程的研究和教育结合起来；3)从代表性不足的群体中招募研究生和本科生参与研究项目。