Ternary Metal-Cyclodextrin-Guest Complexes in Aqueous Solution: Structure and Binding

有了这个新的奖项，有机和高分子化学计划支持教授马修A。Tarr和Branko S.他是新奥尔良大学化学系的一名教授。本研究将研究金属（例如Fe 2+，Ca 2+，Cd 2+），环糊精和可包含在环糊精中的疏水客体分子之间的三元络合物的形成，稳定性和几何形状。 环糊精是一种呈圆柱体形式的多糖。 几个新的定义明确的环糊精衍生物含有各种功能团能够螯合各种金属将被合成，这些化合物将使用吸光度，荧光和NMR光谱进行研究，以确定结合常数和几何形状的三元复合物。 为了决定将合成哪些环糊精衍生物，将采用分子建模。研究结果将推进环境修复和废物流处理技术，将产生新的药物输送策略和工具，并将为理解金属催化反应提供新的模型和见解。这项研究将导致新的环糊精衍生物的合成和这些化合物如何与其他物种相互作用的理解的进展。 此外，它将涉及研究生，本科生，高中教师沿着与高中学生在一个团队设置工作。 研究生将获得指导机会，本科和高中参与者将接触到研究。 教师将接受培训，将他们的研究经验纳入教学，从而改善中学科学教育。 教师将来自少数民族学校;因此，对学生的影响将增加未来科学家的多样性。

With this new award, the Organic and Macromolecular Chemistry Program supports the work of Professors Matthew A. Tarr and Branko S. Jursic of the Chemistry Department at the University of New Orleans. This research will investigate the formation, stability, and geometry of ternary complexes between metals (e.g. Fe2+, Ca2+, Cd2+), cyclodextrins, and hydrophobic guest molecules that can be included in the cyclodextrin. A cyclodextrin is a polysaccharide which takes the form of a cylinder. Several new well defined cyclodextrin derivatives containing a variety of functional groups capable of chelating various metals will be synthesized and these compounds will be studied using absorbance, fluorescence, and NMR spectroscopy in order to determine binding constants and geometries of the ternary complexes. To decide which cyclodextrin derivatives will be synthesized molecular modeling will be employed. Results of the study will advance environmental remediation and waste stream treatment technologies, will produce new strategies and tools for drug delivery, and will provide new models and insight for understanding metal catalyzed reactions.Broader Impacts. This research will result in advances in both synthesis of new cyclodextrin derivatives and an understanding of how these compounds interact with other species. Further, it will involve graduate students, undergraduate students, and high school teachers along with high school students working in a team setting. The graduate students will receive mentoring opportunities, and undergraduate and high school participants will be exposed to research. Teachers will receive training on incorporating their research experiences into teaching, thereby improving secondary science education. Teachers will be from minority-serving schools; therefore, impacts on their students will increase diversity among future scientists.