Powerful new methods for the synthesis of peptides: catalytic oxidation reactions tested to the limit

强大的肽合成新方法：催化氧化反应已达到极限

• 批准号: EP/K024183/1
• 负责人: Timothy Donohoe
• 金额: $ 28.68万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FK024183%2F1
• 关键词: Powerful; new; methods; synthesis; peptides

Chemistry is a dynamic subject that is at the centre of many different scientific advances. Organic chemistry is concerned with the reactivity of carbon in all its different forms and can be viewed as the chemistry taking place within living things. Chemists are constantly looking for new ways of designing and building molecules (synthetic chemistry is molecular architecture) and this proposal describes a short and powerful new way of making valuable compounds, based on peptides, by using new catalytic reactions. Peptides are important because they are the sequences of amino acids that are absolutely essential to the processes of life; we are attempting to make peptides in a fundamentally new way that will give us great control over the nature of the structures that we make and which will allow us to make natural and unnatural peptides that can be tested as potential new medicines.Developing, and testing the limits of, new catalytic reactions is also central to this project, and is also a worthwhile endeavour. The development and application of new catalysts and catalytic systems is important because it makes chemical reactions run faster, and become cleaner with less waste: this is clearly a good thing for industry and also for the environment. To underscore the importance of the compounds that feature in this proposal, peptides can be found in several drugs that have sales of over 1 billion dollars. The novel chemistry proposed here will provide a new, efficient and powerful way of making peptides using catalysis to control functional group incorporation: this will be of great benefit to both academia and industry. Plans have also been made to screen the compounds that we make for a wide range of biological activity.Given all of the above, it is imperative that we have novel, efficient and powerful methods for making new peptide derivatives so that we can study and use them.

化学是一门充满活力的学科，是许多不同科学进步的中心。有机化学研究各种不同形式的碳的反应性，可以看作是发生在生物体内的化学反应。化学家们一直在寻找设计和构建分子的新方法（合成化学就是分子结构），而这一提议描述了一种以肽为基础，利用新的催化反应制造有价值化合物的简短而有力的新方法。肽之所以重要，是因为它们是对生命过程绝对必要的氨基酸序列；我们正在尝试用一种全新的方法来制造多肽，这将使我们能够更好地控制我们所制造的结构的本质，这将使我们能够制造出天然和非天然的多肽，这些多肽可以作为潜在的新药进行测试。开发和测试新的催化反应的极限也是这个项目的核心，也是一项值得努力的工作。新型催化剂和催化系统的开发和应用是很重要的，因为它使化学反应进行得更快，更清洁，浪费更少：这显然对工业和环境都是一件好事。为了强调该提案中化合物的重要性，可以在销售额超过10亿美元的几种药物中发现肽。本文提出的新化学方法将为利用催化控制官能团结合合成多肽提供一种新的、有效的、强有力的方法，这将对学术界和工业界都有很大的好处。我们还计划筛选我们制造的具有广泛生物活性的化合物。鉴于以上种种，我们必须有新颖、高效和强大的方法来制造新的肽衍生物，以便我们能够研究和利用它们。