Molecular Recognition for Highly Regioselective Oxidation Catalysis

高区域选择性氧化催化的分子识别

基本信息

  • 批准号:
    0614403
  • 负责人:
  • 金额:
    $ 45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-09-01 至 2009-12-31
  • 项目状态:
    已结题

项目摘要

Professor Robert Crabtree of Yale University is supported by the Inorganic, Bioinorganic and Organometallic Chemistry program to develop selective oxidation catalysts that utilize molecular recognition to position a remote substrate for stereocontrolled oxidation. Porphyrins and terpyridines with a linker holding a triacid recognition element serve as chelating ligands to dictate substrate geometry relative to the catalytic Mn or Fe site. Target oxidation sites include C-H bonds remote from the tether that will be stereoselectively converted to alcohol products. This project includes mechanistic tests and extensions to complex substrates like dihydrocholesterol that contain multiple CH bonds. Binding the catalysts to a titanium dioxide surface provides opportunities for realizing heterogeneous catalysis with these reagents. Development of efficient oxidation catalysts is important for both bulk and fine chemical processes. Students supported by this award will be exposed to a wide range of chemical techniques that are important in catalysis, and they will utilize both coordination chemistry knowledge and organic synthetic skills.
耶鲁大学的罗伯特·克拉布特里教授得到了无机化学、生物无机化学和金属有机化学计划的支持,开发了选择性氧化催化剂,利用分子识别来定位远程底物,用于立体控制的氧化。带有带有三酸识别元件的连接体的卟啉和三联吡啶作为螯合配体来决定底物相对于催化的锰或铁中心的几何构型。目标氧化位置包括远离系绳的C-H键,这些C-H键将被立体选择性地转化为酒精产品。该项目包括机械测试和对复杂底物的扩展,如包含多个CH键的二氢胆固醇。将催化剂结合到二氧化钛表面为实现这些试剂的多相催化提供了机会。开发高效的氧化催化剂对大宗和精细化工过程都具有重要意义。获得该奖项支持的学生将接触到在催化中重要的广泛的化学技术,他们将利用配位化学知识和有机合成技能。

项目成果

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Robert Crabtree其他文献

Robert Crabtree的其他文献

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{{ truncateString('Robert Crabtree', 18)}}的其他基金

EAGER: Developing and Integrating Advanced NEON AOP Data Products in the Yellowstone Ecosystem
EAGER:在 Yellowstone 生态系统中开发和集成先进的 NEON AOP 数据产品
  • 批准号:
    1444353
  • 财政年份:
    2014
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
SBIR Phase II: FireScape: A Platform for On-Demand, Browser-Based Incident Command
SBIR 第二阶段:FireScape:基于浏览器的按需事件指挥平台
  • 批准号:
    0750514
  • 财政年份:
    2008
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
FSML: Improvement of the Yellowstone Ecological Research Center's Field Station to Support Collaborative Research and Education in the Greater Yellowstone Ecosystem
FSML:改进黄石生态研究中心的野外站,支持大黄石生态系统的合作研究和教育
  • 批准号:
    0829495
  • 财政年份:
    2008
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Design for Upgrade of an Existing Biological Field Station for Conducting Collaborative Ecological Research in the Greater Yellowstone Ecosystem
现有生物野外站升级设计,以在大黄石生态系统中进行协作生态研究
  • 批准号:
    0533887
  • 财政年份:
    2006
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
SBIR Phase I: Fire Information from REmote-sensing and Weather-models Integrated and Supplied to End-users (FIREWISE)
SBIR 第一阶段:集成遥感和天气模型的火灾信息并提供给最终用户 (FIREWISE)
  • 批准号:
    0611334
  • 财政年份:
    2006
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Novel Application of Hydrogen Bonding in Inorganic Chemistry
氢键在无机化学中的新应用
  • 批准号:
    9610146
  • 财政年份:
    1997
  • 资助金额:
    $ 45万
  • 项目类别:
    Standard Grant
Patterns in Sigma Bond Complexation
西格玛键络合模式
  • 批准号:
    9401739
  • 财政年份:
    1994
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
Chemical and Structural Consequences of H...H, H...X, X...X Interactions in Transition Metal Complexes
过渡金属配合物中 H...H、H...X、X...X 相互作用的化学和结构后果
  • 批准号:
    9101766
  • 财政年份:
    1991
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
On the Design and Study of Robust Catalysts for Alkane Conversion
烷烃转化鲁棒催化剂的设计与研究
  • 批准号:
    8805155
  • 财政年份:
    1988
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant
Studies in Catalytic Alkane Conversion
催化烷烃转化研究
  • 批准号:
    8507636
  • 财政年份:
    1985
  • 资助金额:
    $ 45万
  • 项目类别:
    Continuing Grant

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  • 批准号:
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