Dynamics of Chiral Organolithiums: Enantiomerizations and Resolutions

手性有机锂的动力学：对映体和拆分

• 批准号: 0616352
• 负责人: Robert Gawley
• 金额: --
• 依托单位: University of Arkansas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0616352&HistoricalAwards=false
• 关键词: Dynamics; Chiral; Organolithiums; Enantiomerizations; Resolutions

With this new award, the Organic and Macromolecular Chemistry Program supports the work of Professor Robert E. Gawley, of the Chemistry Department at the University of Arkansas. This research will examine the enantiomerization and resolution dynamics of selected chiral organolithium compounds in the presence and absence of chiral and achiral ligands. Thermodynamic and kinetic data will be obtained in order to build an understanding of the dynamics of these important reactive intermediates. Representative examples of several classes of synthetically relevant chiral organolithiums will be examined in detail. These studies are directed toward developing a set of principles that will provide a foundation for advances in the use of chiral organolithiums in stereoselective synthesis. Since stereoselective synthesis is becoming crucial in the synthesis of pharmaceuticals and other biologically important molecules, these studies are expected to contribute to the solution of important problems at the interface of chemistry and biology. The research will involve an international collaboration and promote learning through direct research experiences for undergraduates, graduates and postdoctorals.

有了这个新的奖项，有机和高分子化学计划支持教授罗伯特E。阿肯色州大学化学系的Gawley说。 本研究将探讨所选手性有机锂化合物在手性及非手性配体存在及不存在下的对映体及拆分动力学。将获得热力学和动力学数据，以建立这些重要的活性中间体的动力学的理解。 几类合成相关的手性有机锂的代表性例子将详细审查。 这些研究是针对发展一套原则，将提供一个基础，在立体选择性合成中使用手性有机锂的进步。由于立体选择性合成在药物和其他生物学重要分子的合成中变得至关重要，这些研究有望有助于解决化学和生物学界面上的重要问题。 该研究将涉及国际合作，并通过本科生，研究生和博士后的直接研究经验促进学习。