U.S.- U.K. Cooperative Research: Lithiated Heterocycles

0000096 Gawley这个为期两年的美国-英国在有机合成化学的合作涉及罗伯特E。Gawley和迈阿密大学的博士后研究员以及埃克塞特大学的Iain Coldham。 合作的目的是开发合成复杂杂环化合物的新方法。 研究人员将扩展他们在氨基有机锂构型稳定性方面的工作。 这两个小组都研究了这些通常不稳定的化合物的反应模式，并建议使用互补的相关但不同的化合物来识别结构特征。 这位美国研究人员为这项合作带来了一种独特的方法来研究和开发不稳定的α-锂胺。 这一点得到了英国的补充。研究人员对化合物的结构和制备的专业知识。 他的实验室制备了一种化合物，即使在室温下也表现出构型稳定性。 该项目将促进对合成复杂氮杂环的新方法和有机合成科学的理解。 杂环化合物对药理学很重要，因为绝大多数药物含有通常在该系统中发现的分子的环状排列。

0000096GawleyThis two-year award for U.S.-U.K. collaboration in organic synthetic chemistry involves Robert E. Gawley and a postdoctoral researcher from the University of Miami and Iain Coldham of the University of Exeter. The objective of the collaboration is to develop new methods for the synthesis of complex heterocyclic compounds. The investigators will extend their work on the configurational stability of aminoorganolithiums. Both groups have studied reactivity patterns in these generally unstable compounds and propose to identify structural characteristics using complementary sets of related, yet different compounds. The U.S. investigator brings to this collaboration a unique approach to the study and development of unstabilized alpha-lithio amines. This is complemented by the U.K. investigator's expertise on the structure and preparation of the compounds. His laboratory prepared a compound that demonstrated configurational stability even at room temperature. The project will advance understanding of new methods for synthesizing complex nitrogen heterocycles and of the science of organic synthesis. Heterocyclic compounds are important to pharmacology because the vast majority of pharmaceutical drugs contain the cyclical arrangement of molecules that are typically found in this system.