U.S.- U.K. Cooperative Research: Lithiated Heterocycles

0000096Gawley这个为期两年的奖项旨在表彰美英在有机合成化学领域的合作，获奖者包括罗伯特·E·高利和迈阿密大学的博士后研究员，以及埃克塞特大学的伊恩·科尔德姆。合作的目标是开发合成复杂杂环化合物的新方法。研究人员将继续他们在氨基有机硫化物构型稳定性方面的工作。两个小组都研究了这些通常不稳定的化合物的反应模式，并建议使用相关但不同的化合物的互补集来确定结构特征。这位美国研究人员为这次合作带来了一种研究和开发不稳定的α-锂硫代胺的独特方法。此外，英国研究人员在化合物结构和制备方面的专业知识也起到了补充作用。他的实验室准备了一种即使在室温下也能显示出构型稳定性的化合物。该项目将促进对合成复杂氮杂环的新方法和有机合成科学的理解。杂环化合物对药理学很重要，因为绝大多数药物都包含这个系统中典型的分子的循环排列。

0000096GawleyThis two-year award for U.S.-U.K. collaboration in organic synthetic chemistry involves Robert E. Gawley and a postdoctoral researcher from the University of Miami and Iain Coldham of the University of Exeter. The objective of the collaboration is to develop new methods for the synthesis of complex heterocyclic compounds. The investigators will extend their work on the configurational stability of aminoorganolithiums. Both groups have studied reactivity patterns in these generally unstable compounds and propose to identify structural characteristics using complementary sets of related, yet different compounds. The U.S. investigator brings to this collaboration a unique approach to the study and development of unstabilized alpha-lithio amines. This is complemented by the U.K. investigator's expertise on the structure and preparation of the compounds. His laboratory prepared a compound that demonstrated configurational stability even at room temperature. The project will advance understanding of new methods for synthesizing complex nitrogen heterocycles and of the science of organic synthesis. Heterocyclic compounds are important to pharmacology because the vast majority of pharmaceutical drugs contain the cyclical arrangement of molecules that are typically found in this system.