The Chemistry of N-Confused Porphyrin: Metalation and Model Complexes

N-混淆卟啉的化学：金属化和模型配合物

• 批准号: 0616416
• 负责人: Christopher Ziegler
• 金额: $ 30.6万
• 依托单位: University of Akron
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0616416&HistoricalAwards=false
• 关键词: Chemistry; Confused; Porphyrin; Metalation; Model

Professor Christopher J. Ziegler of the University of Akron is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program to explore the syntheses and characterization of N-confused porphyrins. These novel ligands are isomers of the porphyrin ligands that are found in the active sites of many proteins. In N-confused porphyrins, one of the pyrrole rings has been inverted. These macrocycles are known to stabilize unique oxidation states and coordination environments about their metal centers. Biologically relevant molecules (peptide systems), chromophore assemblies, and heterobimetallic constructs can be coupled to the N-confused porphyrin via the functionalization of the peripheral nitrogen. With these modified ligands, small molecule reactivities (binding to CO and NO) will be studied. This research may be applied to biological and catalytic systems and the planned studies should provide excellent training for underprivileged high school students (sponsored through the American Chemical Society's Project SEED Program) as well as undergraduate and graduate students. Prof. Ziegler has been instrumental in developing the infrastructure of the Department of Chemistry at the University of Akron (through grants from the NSF-Major Research Instrumentation (MRI) Program); this research utilizes the recently required chemical instrumentation.

阿克伦大学的克里斯托弗·J·齐格勒教授得到了无机、生物无机和有机化学项目的支持，以探索N-混乱卟啉的合成和表征。这些新的配体是在许多蛋白质的活性位点中发现的卟啉配体的异构体。 在N-溷乱卟啉中，其中一个吡咯环被倒转。 已知这些大环稳定其金属中心周围的独特氧化态和配位环境。 生物相关分子（肽系统），发色团组件，和杂环结构可以耦合到N-混乱的卟啉通过外围氮的官能化。 这些修饰的配体，小分子的反应性（结合CO和NO）将进行研究。 这项研究可应用于生物和催化系统，计划的研究应提供良好的培训贫困高中学生（通过美国化学学会的项目种子计划赞助）以及本科生和研究生。 齐格勒教授一直致力于发展阿克伦大学化学系的基础设施（通过NSF主要研究仪器（MRI）计划的赠款）;这项研究利用了最近需要的化学仪器。