The Chemistry of N-Confused Porphyrin: Metalation and Model Complexes

阿克伦大学教授Christopher J.Ziegler在无机化学、生物无机化学和金属有机化学项目的支持下，探索N-混乱的卟啉的合成和表征。这些新的配体是卟啉配体的异构体，这些配体存在于许多蛋白质的活性部位。在N-混乱的卟啉中，其中一个吡咯环被颠倒了。众所周知，这些大环可以稳定金属中心周围独特的氧化状态和配位环境。生物相关的分子(多肽系统)、发色团组件和异双金属结构可以通过外周氮的官能化作用偶联到N-混淆的卟啉上。利用这些修饰的配体，将研究小分子的反应性(与CO和NO的结合)。这项研究可以应用于生物和催化系统，计划中的研究应该为贫困高中生(由美国化学学会的种子计划资助)以及本科生和研究生提供极好的培训。齐格勒教授在阿克伦大学化学系的基础设施建设中发挥了重要作用(通过NSF-主要研究仪器(MRI)计划的资助)；这项研究利用了最近需要的化学仪器。

Professor Christopher J. Ziegler of the University of Akron is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program to explore the syntheses and characterization of N-confused porphyrins. These novel ligands are isomers of the porphyrin ligands that are found in the active sites of many proteins. In N-confused porphyrins, one of the pyrrole rings has been inverted. These macrocycles are known to stabilize unique oxidation states and coordination environments about their metal centers. Biologically relevant molecules (peptide systems), chromophore assemblies, and heterobimetallic constructs can be coupled to the N-confused porphyrin via the functionalization of the peripheral nitrogen. With these modified ligands, small molecule reactivities (binding to CO and NO) will be studied. This research may be applied to biological and catalytic systems and the planned studies should provide excellent training for underprivileged high school students (sponsored through the American Chemical Society's Project SEED Program) as well as undergraduate and graduate students. Prof. Ziegler has been instrumental in developing the infrastructure of the Department of Chemistry at the University of Akron (through grants from the NSF-Major Research Instrumentation (MRI) Program); this research utilizes the recently required chemical instrumentation.