LATERAL GENE TRANSFER, GENOME EVOLUTION AND THE EMERGENCE OF NEW DISEASES CAUSED BY FUNGAL PATHOGENS IN THE PLEOSPORALES

侧孢子目真菌病原体引起的横向基因转移、基因组进化和新疾病的出现

• 批准号: DP0987871
• 负责人: Prof Richard Oliver
• 金额: $ 16.76万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0987871
• 关键词: LATERAL; GENE; TRANSFER; GENOME; EVOLUTION

Normal evolution involves the transfer of genes within species. The modest variation between progeny powers natural selection. Lateral gene transfer is the movement of genetic material between species. It allows for large evolutionary steps. Although common in bacteria, it has rarely been described convincingly in higher organisms such as fungi, plants or animals. We have evidence that one group of fungal pathogens is particularly adept at acquiring new genes that enable them to cause new diseases. We will determine the mechanism and frequency of gene transfer in this group. The work had fundamental significance in evolutionary biology, in the emergence of new diseases and in the use of genetically-modified organisms.

正常的进化涉及物种内基因的转移。后代之间的适度差异促进了自然选择。横向基因转移是遗传物质在物种之间的移动。它允许大的进化步骤。尽管在细菌中很常见，但在真菌、植物或动物等高等生物中却很少有令人信服的描述。我们有证据表明，一组真菌病原体特别擅长获得新基因，从而能够引起新疾病。我们将确定该组中基因转移的机制和频率。这项工作对于进化生物学、新疾病的出现以及转基因生物的使用具有根本意义。