Why are many fungicide lead compounds active against pathogens in axenic culture but inactive when applied to infected plants?
为什么许多杀菌剂先导化合物在无菌培养中对病原体有活性,但在应用于受感染的植物时却无效?
基本信息
- 批准号:LP0346963
- 负责人:
- 金额:$ 19.9万
- 依托单位:
- 依托单位国家:澳大利亚
- 项目类别:Linkage Projects
- 财政年份:2003
- 资助国家:澳大利亚
- 起止时间:2003-08-21 至 2006-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
It is much cheaper and easier to screen compounds for fungicidal activity in vivo (that is against the fungus grown in axenic culture) than to test in planta. However, it is commonly observed that compounds active in in vivo screens do not subsequently prove to be active in planta. The aim of this project is to investigate the physiological, biochemical and genetics basis of this discrepancy and to attempt to provide tools that circumvent the problem. It is expected the project will generate novel information on the environment in the plant experienced by the fungus.
在体内筛选化合物的杀真菌活性(即对抗无菌培养物中生长的真菌)比在植物中测试便宜得多,也容易得多。然而,通常观察到在体内筛选中有活性的化合物随后不能证明在植物中有活性。该项目的目的是调查这种差异的生理,生化和遗传学基础,并试图提供规避问题的工具。预计该项目将产生有关真菌所经历的植物环境的新信息。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Prof Richard Oliver其他文献
Prof Richard Oliver的其他文献
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{{ truncateString('Prof Richard Oliver', 18)}}的其他基金
LATERAL GENE TRANSFER, GENOME EVOLUTION AND THE EMERGENCE OF NEW DISEASES CAUSED BY FUNGAL PATHOGENS IN THE PLEOSPORALES
侧孢子目真菌病原体引起的横向基因转移、基因组进化和新疾病的出现
- 批准号:
DP0987871 - 财政年份:2009
- 资助金额:
$ 19.9万 - 项目类别:
Discovery Projects
Western Australian Facility for High Throughput Biological and Organic Gas Chromatography-Mass Spectrometry
西澳大利亚高通量生物和有机气相色谱-质谱设施
- 批准号:
LE0668536 - 财政年份:2006
- 资助金额:
$ 19.9万 - 项目类别:
Linkage Infrastructure, Equipment and Facilities
Genomic Synteny in Legumes; Application to Crop Breeding
豆类的基因组同线性;
- 批准号:
LP0454871 - 财政年份:2005
- 资助金额:
$ 19.9万 - 项目类别:
Linkage Projects
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