Cardiovascular Flow Synthesis - A Hybrid Systems Approach

心血管血流合成 - 混合系统方法

• 批准号: 0626170
• 负责人: Bassam Bamieh
• 金额: $ 18.5万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0626170&HistoricalAwards=false
• 关键词: Cardiovascular; Flow; Synthesis; Hybrid; Systems

AbstractHundreds of thousands of patients die from heart failure every year. To address this tremendous need, there are a number of medical devices that continue to be developed including artificial hearts, prosthetic heart valves and intra-aortic balloon pumps. All of these devices are developed in the laboratory, preferably with a minimum of costly animal experiments. To facilitate the development of cardiovascular devices and reduce the number of animal experiments, this project seeks to develop software-controlled precision pumps that can simulate a pumping heart, the impedance of a diseased artery or the collapse of a blood vessel under suction. We will develop mathematical models that enable the optimization of pumping systems to match cardiovascular flow; and control algorithms that address the issues of discontinuities associated with physiologic valve closure and pump friction.

摘要 每年有数十万患者死于心力衰竭。为了满足这一巨大需求，许多医疗设备仍在不断开发中，包括人造心脏、人工心脏瓣膜和主动脉内球囊泵。所有这些设备都是在实验室中开发的，最好进行最少昂贵的动物实验。为了促进心血管设备的开发并减少动物实验的数量，该项目寻求开发软件控制的精密泵，可以模拟泵动的心脏、病变动脉的阻抗或吸力下血管的塌陷。我们将开发数学模型，优化泵送系统以匹配心血管流量；和控制算法，解决与生理阀门关闭和泵摩擦相关的不连续性问题。