The Implications of Heterogeneity for the Philosophy, History, Sociology, and Science of Biological Determinism

异质性对生物决定论的哲学、历史、社会学和科学的影响

基本信息

  • 批准号:
    0634744
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-09-01 至 2009-08-31
  • 项目状态:
    已结题

项目摘要

Quantitative analysis in the study of heredity and in social sciences more generally could be transformed through attention to the possible heterogeneity of factors that underlie observed traits. It is understood in the sociology of science that ideas do not realize their transformative potential simply by being correct; rather, changes in the social structure of the field are needed if the inevitable resistance from the mainstream is to be overcome. Moreover, alternative research programs have to be opened up before many researchers begin to shift; critique is not sufficient for a dominant paradigm to be abandoned. What role can studies of science and society (S&S) have in such change? This Small Grant for Exploratory Research (SGER) proposal identifies a number of angles through which the PI and other S&S scholars might bring attention in research and policy to the implications of heterogeneity. Modest support would allow the PI to pursue two tracks through which novel ideas can "gestate" long enough to command attention, if not acceptance, by a wider audience. The first track would investigate four issues in S&S that extend the PI's recent work on heritability and heterogeneity, and it would subject these investigations at an early, work-in-progress stage to the scrutiny of appropriate audiences and workshops with a view to stimulating specialists to delve deeper into these issues, and mobilizing collaborations and associations to support one other in such emergent research. The second track would explore, through intensive week-long training and discussion visits, a number of scientific approaches that may contribute to developing empirically validated models of developmental pathways whose components are heterogeneous and differ among individuals at any one time and over generations. The combination of S&S investigations and engagement with scientists is designed to promote positive critique of heritability discourse, and to allow the PI to identify the place and direction of most leverage for the PI's unusual combination of interests and skills, which lie not only in S&S but also in quantitative analyses in the life sciences. The PI anticipates submission of a major research proposal on the basis of the SGER-supported work. The intellectual merit of the work lies in the development of ideas that have been overlooked or not well appreciated in the science and S&S studies of "genes and environment," despite the long and politically charged history of scientific and policy debates about the heritability of IQ test scores and genetic explanations of the differences between the mean scores for racial groups. The broader impact will be to move popular discussion beyond problematic ideas about the relative contribution of genes and environment to human traits, shed critical light on the persistent interest in explaining differences among the averages for groups defined on racial grounds, and stimulate scientific and S&S research on developmental pathways in ways that accommodate heterogeneity.
遗传学研究和社会科学中的定量分析可以通过关注观察到的特征背后的因素的可能异质性来改变。科学社会学认为,思想不能仅仅通过正确来实现其变革潜力;相反,如果要克服来自主流的不可避免的阻力,就需要改变该领域的社会结构。此外,在许多研究人员开始转变之前,必须开辟替代研究方案;批评不足以抛弃主导范式。科学与社会研究(S S)在这种变化中可以发挥什么作用?探索性研究(SGER)的建议确定了一些角度,通过这些角度,PI和其他S S学者可能会在研究和政策中关注异质性的影响。适度的支持将允许PI追求两条轨道,通过这两条轨道,新的想法可以“孕育”足够长的时间,以获得更广泛的观众的关注,如果不是接受的话。第一个轨道将调查四个问题在S S扩展PI的遗传性和异质性的最近的工作,它会在早期,工作进展阶段,这些调查适当的观众和研讨会的审查,以刺激专家深入研究这些问题,并动员合作和协会,以支持彼此在这种新兴的研究。第二个轨道将通过为期一周的密集培训和讨论访问,探索一些科学方法,这些方法可能有助于制定经经验验证的发展途径模型,这些模型的组成部分是异质的,在任何一个时间和几代人之间都是不同的。S S调查和参与科学家的结合,旨在促进遗传性话语的积极批评,并允许PI确定PI的兴趣和技能,不仅在S S,而且在生命科学的定量分析的不寻常的组合的最杠杆的地方和方向。PI预计将在SGER支持的工作的基础上提交一项重大研究提案。这项工作的智力价值在于发展的想法,已被忽视或不太赞赏的科学和S S研究的“基因和环境”,尽管长期和政治上充满了历史的科学和政策辩论的遗传性智商测试成绩和遗传解释之间的差异,平均分数的种族群体。更广泛的影响将是移动流行的讨论超越了有问题的想法基因和环境对人类特征的相对贡献,揭示了持续的兴趣在解释种族基础上定义的群体的平均值之间的差异,并刺激科学和S S研究的方式,以适应异质性的发展途径。

项目成果

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Peter Taylor其他文献

The Spirit Level: Why More Equal Societies Almost Always Do Better
  • DOI:
    10.1080/13606710903141476
  • 发表时间:
    2009-03
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Peter Taylor
  • 通讯作者:
    Peter Taylor
Evaluation of joint activation and joint spacing in concrete overlays
混凝土覆盖层接缝激活和接缝间距的评估
  • DOI:
    10.1080/14680629.2021.2005669
  • 发表时间:
    2021-11
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Yu-an Chen;Peter Taylor;Halil Ceylan;Xuhao Wang
  • 通讯作者:
    Xuhao Wang
公共スポーツ施設の管理運営制度に関する研究
公共体育设施管理运营体系研究
Accelerating transitions? Planning for decarbonisation in local and regional energy systems
  • DOI:
    10.1016/j.erss.2024.103875
  • 发表时间:
    2025-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Helen Poulter;Jess Britton;Imogen Rattle;Ronan Bolton;Jan Webb;Peter Taylor
  • 通讯作者:
    Peter Taylor
Correction: Quantifying beta cell function in the preclinical stages of type 1 diabetes
  • DOI:
    10.1007/s00125-024-06335-w
  • 发表时间:
    2024-11-27
  • 期刊:
  • 影响因子:
    10.200
  • 作者:
    Alfonso Galderisi;Alice L. J. Carr;Mariangela Martino;Peter Taylor;Peter Senior;Colin Dayan
  • 通讯作者:
    Colin Dayan

Peter Taylor的其他文献

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{{ truncateString('Peter Taylor', 18)}}的其他基金

[SurgeryNet] Epilepsy surgery induced brain network changes: relation to patient outcomes
[SurgeryNet] 癫痫手术引起的脑网络变化:与患者预后的关系
  • 批准号:
    MR/T04294X/1
  • 财政年份:
    2021
  • 资助金额:
    --
  • 项目类别:
    Fellowship
Biocatalytic Approaches to the Synthetic Manipulation of Silicones
有机硅合成操作的生物催化方法
  • 批准号:
    EP/S013660/1
  • 财政年份:
    2019
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Molecular mechanisms of enterobacterial resistance to complement
肠杆菌补体耐药的分子机制
  • 批准号:
    MR/R009937/1
  • 财政年份:
    2018
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Treatment of multi-drug-resistant Gram-negative bacterial infections using capsule depolymerases
使用胶囊解聚酶治疗多重耐药革兰氏阴性细菌感染
  • 批准号:
    MR/N012542/1
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Consortium for Modelling and Analysis of Decentralised Energy Storage (C-MADEnS)
去中心化储能建模与分析联盟 (C-MADenS)
  • 批准号:
    EP/N001745/1
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Modulation of innate defences in the neonatal gastrointestinal tract by colonizing neuropathogenic Escherichia coli
通过定植神经病原性大肠杆菌来调节新生儿胃肠道的先天防御
  • 批准号:
    MR/K018396/1
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Disruption of cytoplasmic membrane-associated functions in Staphylococcus aureus by epicatechin gallate
表儿茶素没食子酸酯破坏金黄色葡萄球菌细胞质膜相关功能
  • 批准号:
    BB/I005579/1
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Pharmacological evaluation of synthetic galloyl catechin analogues with anti-staphylococcal properties
具有抗葡萄球菌特性的合成没食子酰儿茶素类似物的药理学评价
  • 批准号:
    G0801757/1
  • 财政年份:
    2009
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Modulation of beta-lactam resistance in methicillin-resistant Staphylococcus aureus by catechin gallates
儿茶素没食子酸酯对耐甲氧西林金黄色葡萄球菌的β-内酰胺耐药性的调节
  • 批准号:
    G0600004/1
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:
    Research Grant
Qualification of ultrasonography as a biomarker of prognosis and response to therapy in rheumatoid arthritis
超声检查作为类风湿关节炎预后和治疗反应生物标志物的资格
  • 批准号:
    G0601962/1
  • 财政年份:
    2007
  • 资助金额:
    --
  • 项目类别:
    Research Grant

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RII Track-4:NSF:HEAL:集群和边缘的异质性感知高效自适应学习
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