CRIF:MU Acquisition of a Cyber Enabled Liquid Chromatograph-Mass Spectrometer

阿拉巴马大学塔斯卡卢萨分校化学系将从化学研究仪器和设施：多用户(CRIF：MU)计划中获得一台液体色谱质谱计(LC-MS)。所要求的LC-MS将促进正在进行的研究项目，包括：光合作用系统的辅因子鉴定和蛋白质组分析；阐明铬在人体代谢中的作用及其对胰岛素敏感性和糖尿病治疗的影响；开发用于水相催化的水溶性配体和金属催化的核苷修饰研究；用于一系列工业应用的五氟磺酰基苯和氟化聚合物的制备和表征；以及金属多肽和去质子肽的测序的基础和应用研究。质谱学是物理和生物科学家通过准确测量物质和化学物种在仪器中挥发和碎裂时的质量来识别和表征它们的基本工具。液相色谱是一种净化技术，它将复杂的混合物分离成单独的组分，然后引入质谱仪。这些都是培训青年科学家的重要工具。60多名学生研究人员将在未来几年内在他们的研究项目中使用LC-MS。这包括研究生、本科学年和暑期学生(包括UA NSF REU项目的学生)，以及参加暑期项目的高中教师。通过使用自动取样器和网络控制，位于4个或更多地区性本科机构(包括两个少数族裔服务机构)的教育工作者和研究人员将可以使用该仪器进行实验室课程和本科研究。

The Chemistry Department at the University of Alabama Tuscaloosa will acquire a liquid chromatograph mass spectrometer (LC-MS) with this award from the Chemistry Research Instrumentation and Facilities: Multi User (CRIF:MU) program. The requested LC-MS will facilitate ongoing research projects including: cofactor identification and proteomic analysis of photosynthetic systems; elucidation of the role of chromium in human metabolism and its implications in insulin sensitivity and treatments of diabetes; the development of water-soluble ligands for aqueous-phase catalysis and studies of metal-catalyzed modification of nucleosides; preparation and characterization of pentafluorosulfanyl-benzenes and fluorinated polymers for use in a range of industrial applications; and fundamental and applied studies into the sequencing of metallopeptides and deprotonated peptides.Mass spectroscopy is a basic tool used by physical and biological scientists to identify and characterize materials and chemical species by accurate measurement of their mass as they are vaporized and fragmented in the instrument. Liquid chromatography is a purification technique that separates a complex mixture into individual components before introduced to the mass spectrometer. These are important tools to be used in the training of young scientists. Over 60 student researchers will use LC-MS in their research projects over the next few years. This includes graduate students, undergraduate academic year and summer students (including students from UA's NSF REU program), and high school teachers participating in summer programs. Through the use of an autosampler and cyber-control, educators and researchers located at 4 or more regional undergraduate institutions including two minority serving institutions, will have access to the instrument for the purposes of laboratory classes and undergraduate research.