CRIF:MU Upgrade of Spectroscopy Tools for Biophysics, Surface Chemistry, Single-Molecule Science and Nanotechnology Research and Education

凭借化学研究仪器和设施：多用户计划（CRIF：MU）的这一奖项，斯坦福大学化学系将升级其用于教学和研究的红外和荧光光谱设备，购买具有空间分辨率的红外显微镜、FTIR单层分析和漫反射附件，并升级具有停流模块的荧光计，以实现快速混合功能和反应速率的时间分辨率测量，精确到毫秒级。 这些仪器将用于各种研究项目，包括利用单分子荧光光谱研究蛋白质构象变化，以便与整体测量进行比较;对各种生物系统的研究，包括绿色荧光蛋白变体、振动斯塔克效应光谱和利用空间分辨傅里叶变换红外光谱分析模型膜表面;研究空间解析碳纳米管氢化化学在端部和侧壁与潜在的应用在氢存储和纳米管nanosensors;研究开发碳，包括石墨和碳纳米管的表面功能化化学，重要的燃料电池，电池和生物传感器的发展。 这些仪器将用于将纳米技术元素引入化学系的本科教学中，并计划在实验室课程中进行实验。这些仪器将被本科生，研究生和博士后研究员在他们的研究中使用，并将有利于各种推广计划，如RET，REU和SURE，以及斯坦福大学NSF资助的中心，包括CPIMA和NSEC的研究。

With this award from the Chemistry Research Instrumentation and Facilities: Multi User program (CRIF:MU), the Chemistry Department at Stanford University will upgrade their infra red and fluorescence spectrometry equipment for teaching and research with acquisition of an infrared microscope with spatial resolution, FTIR monolayer analysis and diffuse reflectance accessories, and upgrade a fluorimeter with a stopped-flow module for rapid mixing capabilities and time resolution measurement of reaction rates down to the millisecond regime. The instruments will be used in various research projects including the study of protein conformational changes using single molecule fluorescence spectroscopy to make comparisons with ensemble measurements; investigations of a wide range of biological systems include green fluorescent protein (GFP) variants, vibrational Stark effect (VSE) spectroscopy, and the analysis of model membrane surfaces with spatially resolved FTIR; investigations to spatially resolve carbon nanotube hydrogenation chemistry at the ends and sidewalls with potential applications in hydrogen storage and nanotube nansensors; studies to develop surface functionalization chemistry for carbon, including graphite and carbon nanotubes, important to fuel cells, batteries and biosensor developments. The instruments will be used to introduce a nanotechnology element into undergraduate teaching in the chemistry department with experiments planned for a laboratory course. The instruments will be used by undergraduate, graduate students and postdoctoral fellows in their research and will benefit various outreach programs such as RET, REU and SURE, and the research of NSF-funded centers at Stanford including CPIMA and NSEC.