CRIF:MU Acquisition of a Low Temperature Stopped-Flow System with Cyber-Enabled Access

CRIF:MU 收购具有网络访问权限的低温停流系统

• 批准号: 0639138
• 负责人: Mary Jane Shultz
• 金额: $ 17.7万
• 依托单位: Tufts University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0639138&HistoricalAwards=false
• 关键词: CRIF; MU; Acquisition; Low; Temperature

With this award from the Chemistry Research Instrumentation and Facilities: Multi User program (CRIF:MU), the Chemistry Department at Tufts University will acquire a cryogenic stopped-flow instrument for rapid kinetic measurements. The primary users of this instrument will be: (1) Elena Rybak-Akimova (Tufts University) whose research includes mechanism-based design of selective, efficient, switchable receptors and catalysts for oxidations and small-molecule activation reactions; (2) Daniel Nocera (MIT) whose research interests include developing chemical systems for solar energy conversion, and fundamental understanding of complicated oxidation-reduction mechanisms; (3) William Armstrong (Boston College) whose research interests include understanding and modeling of the active site of the water-oxidizing complex in Photosystem II; (4) John Caradonna (Boston University) who is developing catalysts for green alkane oxidations; (5) Richard Holm (Harvard) whose research is centered around understanding nitrogen fixation by nitrogenase, and oxygen atom transfers by molybdenum- and tungsten oxidative enzymes; (6) Christopher Cummins (MIT) whose research focuses on utilization of atmospheric nitrogen and other pnictogens, understanding the mechanisms of atom and group transfer, and timing and taming radical chemistry through coordination to metal centers.A stopped flow instrument is used to investigate the speed of chemical reactions, often very fast reactions. This cryogenic instrument will operate over a broad temperature range and reach temperatures as low as -90 degrees C. Graduate students and postdoctoral fellows will be trained in this specialized methodology. They will learn to use a rational, mechanism-based approach in chemical research, and will be exposed to research ideas, culture, and methodologies from several groups. Rapid kinetics methodology will be incorporated in upper-level undergraduate courses. The remote access to data acquisition and processing will advance cyber-infrastructure for chemistry research.

有了化学研究仪器和设施：多用户计划(CRIF：MU)的这一奖项，塔夫茨大学化学系将获得一台用于快速动力学测量的低温停流仪器。该仪器的主要用户将是：(1)Elena Rybak-Akimova(塔夫茨大学)，他的研究包括为氧化和小分子激活反应设计选择性、高效、可切换的受体和催化剂；(2)Daniel Nocera(麻省理工学院)，他的研究兴趣包括开发太阳能转换的化学系统，并对复杂的氧化还原机制有基本的了解；(3)William Armstrong(波士顿学院)，他的研究兴趣包括了解和模拟光系统II中水氧化复合体的活性部位；(4)John Caradonna(波士顿大学)，他正在开发绿色烷烃氧化催化剂；(5)理查德·霍尔姆(哈佛)，他的研究集中在了解固氮酶的固氮作用以及钼和钨氧化酶的氧原子转移方面；(6)克里斯托弗·康明斯(麻省理工学院)，他的研究重点是利用大气中的氮和其他化学物质，了解原子和基团转移的机制，以及通过与金属中心配位来控制和驯服自由基化学。这种低温仪器将在很宽的温度范围内运行，温度低至零下90摄氏度。研究生和博士后研究员将接受这一专门方法的培训。他们将学会在化学研究中使用理性的、以机制为基础的方法，并将接触到来自几个小组的研究想法、文化和方法。快速动力学方法将被纳入高水平的本科课程。数据采集和处理的远程访问将推进化学研究的网络基础设施。