Partial Selfing and the Genetic Basis of Mating System Variation

部分自交和交配系统变异的遗传基础

• 批准号: 0641066
• 负责人: Patrick Phillips
• 金额: --
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0641066&HistoricalAwards=false
• 关键词: Partial; Selfing; Genetic; Basis; Mating

Variation in mating systems is one of the primary determinants of the pattern of genetic variation within plant and animal populations. The cause of these differences, both in terms of proximate genetic changes and ultimate ecological outcomes, is almost completely unknown except in a few specialized cases. This project aims to undercover the genetic basis of mating system variation within the well-studied nematode model system, Caenorhabditis elegans, and to use this information together with predictions from theoretical models to investigate how changing levels of mutational input affect the transition between different forms of sexual reproduction. Mating system genetics will be assessed using high throughput functional genomic approaches, and the predictions will be tested experimentally using direct genetic manipulation of mutation rate and an individual's propensity to produce male offspring.This research should further our understanding of the mechanisms responsible for generating the tremendous variation in mating systems in both plants and animals. The processes studied here are fundamental to describing variation and change in agricultural and natural systems, especially in endangered species of plants and animals. Nematodes themselves are one of the most numerous, yet understudied, groups of organisms on earth and are important animal and plant pathogens.

交配系统的变异是动植物种群内遗传变异模式的主要决定因素之一。这些差异的原因，无论是在最近的遗传变化和最终的生态结果，几乎是完全未知的，除了在少数特殊情况下。该项目的目的是隐藏的遗传基础的交配系统的变异内的线虫模型系统，秀丽隐杆线虫，并使用这些信息与理论模型的预测，以调查如何改变水平的突变输入影响不同形式的有性生殖之间的过渡。交配系统遗传学将使用高通量功能基因组学方法进行评估，预测将通过直接遗传操作突变率和个体产生雄性后代的倾向进行实验测试。这项研究将进一步加深我们对植物和动物交配系统产生巨大变化的机制的理解。这里研究的过程是描述农业和自然系统，特别是濒危动植物物种的变异和变化的基础。线虫本身是地球上数量最多但研究不足的生物群体之一，是重要的动植物病原体。