OPUS: Evolution of Genetic Architecture

生物的复杂性建立在构成所有生物功能的分子成分之上。几十年来在遗传学方面的仔细工作，加上最近的基因组学革命，帮助确定了这些过程中的许多核心参与者。然而，仍然存在两个相当大的问题：(1)这些组件如何相互作用以产生一个完整的有机体；(2)整个组件和相互作用系统如何随着时间的推移而演变？该奖项支持出版一本书，通过关注基因结构的进化来解决这些问题，将数量遗传学和分子进化的历史观点与遗传系统结构的最新信息相结合，以提供对我们当前知识状况的视角和对未来研究的展望。这项工作将进一步加深我们对复杂特征的遗传基础的理解，这些特征是所有有机体的特征，但也正在成为农业、生物医学和人类健康研究的突出焦点。鉴于目前可获得的大量遗传信息，现在是进行综合的合适时机，这将确定现有的优势并确定未来的研究重点。这本书的目的是广泛接触到所有级别的生物学家，因此将对研究人员和学生都有用。

Biological complexity is built upon molecular components that underlie all biological function. Decades of careful work in genetics, together with the recent revolution in genomics, has helped to identify many of the central players in these processes. However, two rather large questions remain: (1) how do these components interact with one another to generate an entire organism and (2) how does the entire system of components and interactions evolve through time? This award supports the production of a book that addresses these questions by focusing on the evolution of genetic architecture, synthesizing historical views of quantitative genetics and molecular evolution with recent information on the structure of genetic systems to provide a perspective on our current state of knowledge and a prospective for future research.This work will further our understanding of the genetic basis of the complex traits that characterize all organisms, but which are also becoming a prominent focus of research in agriculture, biomedicine, and human health. Given the tremendous amounts of genetic information currently available, now is an appropriate time for a synthesis that will identify existing strengths and establish future research priorities. This book is intended to be widely accessible to biologists at all levels and will thus be useful for both researchers and students alike.