OPUS: Evolution of Genetic Architecture

OPUS：遗传结构的进化

• 批准号: 0614588
• 负责人: Patrick Phillips
• 金额: $ 14.21万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2009-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0614588&HistoricalAwards=false
• 关键词: OPUS; Evolution; Genetic; Architecture

Biological complexity is built upon molecular components that underlie all biological function. Decades of careful work in genetics, together with the recent revolution in genomics, has helped to identify many of the central players in these processes. However, two rather large questions remain: (1) how do these components interact with one another to generate an entire organism and (2) how does the entire system of components and interactions evolve through time? This award supports the production of a book that addresses these questions by focusing on the evolution of genetic architecture, synthesizing historical views of quantitative genetics and molecular evolution with recent information on the structure of genetic systems to provide a perspective on our current state of knowledge and a prospective for future research.This work will further our understanding of the genetic basis of the complex traits that characterize all organisms, but which are also becoming a prominent focus of research in agriculture, biomedicine, and human health. Given the tremendous amounts of genetic information currently available, now is an appropriate time for a synthesis that will identify existing strengths and establish future research priorities. This book is intended to be widely accessible to biologists at all levels and will thus be useful for both researchers and students alike.

生物的复杂性是建立在所有生物功能的基础上的分子组成部分。几十年来在遗传学方面的细致工作，加上最近的基因组学革命，有助于确定这些过程中的许多核心角色。然而，两个相当大的问题仍然存在：（1）这些组件如何相互作用以产生整个有机体;（2）整个组件和相互作用系统如何随时间演变？该奖项支持一本书的制作，通过关注遗传结构的进化来解决这些问题，将数量遗传学和分子进化的历史观点与遗传系统结构的最新信息相结合，为我们当前的知识水平提供一个视角，并为未来的研究提供一个前景。这项工作将进一步加深我们对复杂性状的遗传基础的理解，所有生物，但也成为农业，生物医学和人类健康研究的一个突出重点。鉴于目前可获得的遗传信息量巨大，现在是进行综合的适当时机，以确定现有的优势并确定未来的研究重点。这本书的目的是广泛接触到各级生物学家，因此将是有用的研究人员和学生一样。