Mating systems and the origins of genetic conflict

交配系统和遗传冲突的起源

• 批准号: 1120417
• 负责人: Patrick Phillips
• 金额: $ 77.5万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-15 至 2015-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1120417&HistoricalAwards=false
• 关键词: Mating; systems; origins; genetic; conflict

Physical and chemical interactions between individuals are a necessary part of normal reproduction, yet in many animals, differing reproductive goals of males and females sometimes leads to a genetic conflict between the sexes. This project uses the power of the well-studied nematode model system, Caenorhabditis elegans, which reproduces primarily via self-reproduction, and its close relative C. remanei, which has separate males and females, to examine the genetic basis of reproductive interactions. This project uses comprehensive genomic and proteomic approaches to identify the genetic bases of male reproductive traits and antagonistic effects in both C. elegans and C. remanei natural isolates, as well as in C. elegans populations that have been genetically manipulated to reproduce via outcrossing instead of self-reproduction.Reproduction is a defining characteristic of living systems, and understanding the genetic and functional basis of reproductive interactions can provide key insights about the forces that maintain the tremendous diversity that we see in the world. Infertility affects more than six million Americans each year, with many of these cases being caused by mysterious incompatibilities between the perspective parents. Many basic biological functions are conserved across all animals, so identifying the genes and proteins involved in reproductive interactions in these species may yield insights into similar interactions in other organisms, including humans.

个体之间的物理和化学相互作用是正常繁殖的必要组成部分，然而在许多动物中，雄性和雌性的不同繁殖目标有时会导致两性之间的基因冲突。该项目利用线虫模型系统的力量，秀丽隐杆线虫（主要通过自我繁殖繁殖）和它的近亲C. remanei（有单独的雄性和雌性）来研究生殖相互作用的遗传基础。本项目利用全面的基因组学和蛋白质组学方法，确定秀丽隐杆线虫和雷马尼隐杆线虫天然分离株，以及通过基因操纵通过异交而非自交繁殖的秀丽隐杆线虫种群的雄性生殖性状和拮抗作用的遗传基础。生殖是生命系统的一个决定性特征，了解生殖相互作用的遗传和功能基础可以为我们了解维持我们在世界上看到的巨大多样性的力量提供关键的见解。每年有超过600万美国人患有不孕症，其中许多病例是由潜在父母之间神秘的不相容引起的。许多基本的生物学功能在所有动物中都是保守的，因此，识别这些物种中涉及生殖相互作用的基因和蛋白质，可能会对包括人类在内的其他生物中类似的相互作用产生见解。