Tuberculosis Treatment Trials

结核病治疗试验

基本信息

  • 批准号:
    MC_UU_12023/27
  • 负责人:
  • 金额:
    $ 466.61万
  • 依托单位:
  • 依托单位国家:
    英国
  • 项目类别:
    Intramural
  • 财政年份:
    2015
  • 资助国家:
    英国
  • 起止时间:
    2015 至 无数据
  • 项目状态:
    已结题

项目摘要

Tuberculosis remains a major problem in many countries; in sub-Saharan Africa numbers of cases reported have increased dramatically following the advent of the HIV-AIDS epidemic. Treatment regimens for drug-sensitive tuberculosis which are highly effective under controlled trial conditions have been available for many years but need to be given for at least 6 months. Many patients fail to complete treatment since they feel much better after 2-3 months treatment. Shorter and simpler effective regimens are needed. The CTU recently completed two international multi-centre trials assessing the possibility of treatment shortening and/or simplifying treatment. A trial assessing ultra-short treatment has been funded and is planned to commence in the near future. There is an urgent need to find effective treatments for multi-drug resistant tuberculosis (MDR-TB), current regimens are given for long durations, are toxic, expensive and results are generally poor. A large multi-centre trial is currently in progress which is assessing a promising regimen which has been developed in Bangladesh; the trial includes two regimens containing the first new tuberculosis drug to be licensed for about 50 years. There have been very few trials of tuberculosis treatment in children, one such trial in children with limited disease is expected to start soon and trials in drug-resistant tuberculosis and TB-meningitis are planned.
结核病在许多国家仍然是一个主要问题;在撒哈拉以南非洲,在艾滋病毒/艾滋病疫情出现后,报告的病例数量急剧增加。药物敏感型结核病的治疗方案在受控试验条件下非常有效,已经存在多年,但需要至少服用6个月。许多患者未能完成治疗,因为他们在治疗2-3个月后感觉好多了。需要更短、更简单的有效方案。反恐联盟最近完成了两项国际多中心试验,评估缩短和/或简化治疗的可能性。一项评估超短波治疗的试验已经获得资金,并计划在不久的将来开始。目前迫切需要找到治疗耐多药结核病(MDR-TB)的有效方法,目前的治疗方案疗程长、毒性大、费用高,而且效果普遍较差。目前正在进行一项大型多中心试验,该试验正在评估孟加拉国开发的一种有希望的方案;该试验包括两种方案,其中含有大约50年来获得许可的第一种结核病新药。儿童结核病治疗的试验非常少,预计很快就会开始一项针对有限疾病儿童的试验,并计划进行耐药结核病和结核病脑膜炎的试验。

项目成果

期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Pharmacokinetics, Tolerability, and Bacteriological Response of Rifampin Administered at 600, 900, and 1,200 Milligrams Daily in Patients with Pulmonary Tuberculosis
  • DOI:
    10.1128/aac.01054-17
  • 发表时间:
    2017-11-01
  • 期刊:
  • 影响因子:
    4.9
  • 作者:
    Aarnoutse, R. E.;Kibiki, G. S.;Boeree, M. J.
  • 通讯作者:
    Boeree, M. J.
Discontinuing cotrimoxazole preventive therapy in HIV-infected adults who are stable on antiretroviral treatment in Uganda (COSTOP): A randomised placebo controlled trial.
  • DOI:
    10.1371/journal.pone.0206907
  • 发表时间:
    2018-01-01
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Anywaine, Zacchaeus;Levin, Jonathan;Munderi, Paula
  • 通讯作者:
    Munderi, Paula
High-dose rifampicin, moxifloxacin, and SQ109 for treating tuberculosis: a multi-arm, multi-stage randomised controlled trial.
  • DOI:
    10.1016/s1473-3099(16)30274-2
  • 发表时间:
    2017-01
  • 期刊:
  • 影响因子:
    56.3
  • 作者:
    Boeree, Martin J.;Heinrich, Norbert;Aarnoutse, Rob;Diacon, Andreas H.;Dawson, Rodney;Rehal, Sunita;Kibiki, Gibson S.;Churchyard, Gavin;Sanne, Ian;Ntinginya, Nyanda E.;Minja, Lilian T.;Hunt, Robert D.;Charalambous, Salome;Hanekom, Madeleine;Semvua, Hadija H.;Mpagama, Stellah G.;Manyama, Christina;Mtafya, Bariki;Reither, Klaus;Wallis, Robert S.;Venter, Amour;Narunsky, Kim;Mekota, Anka;Henne, Sonja;Colbers, Angela;van Balen, Georgette Plemper;Gillespie, Stephen H.;Phillips, Patrick P. J.;Hoelscher, Michael
  • 通讯作者:
    Hoelscher, Michael
Type I error rates of multi-arm multi-stage clinical trials: strong control and impact of intermediate outcomes.
  • DOI:
    10.1186/s13063-016-1382-5
  • 发表时间:
    2016-07-02
  • 期刊:
  • 影响因子:
    2.5
  • 作者:
    Bratton DJ;Parmar MK;Phillips PP;Choodari-Oskooei B
  • 通讯作者:
    Choodari-Oskooei B
STREAM: a pragmatic and explanatory trial for MDR-TB treatment.
STREAM:耐多药结核病治疗的务实和解释性试验。
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Patrick Phillips其他文献

Telephone follow-up for patients eligible for cardiac rehab: A systematic review
对符合心脏康复资格的患者进行电话随访:系统评价
Advanced airway management in hoist and longline operations in mountain HEMS – considerations in austere environments: a narrative review This review is endorsed by the International Commission for Mountain Emergency Medicine (ICAR MEDCOM)
that Determine Quality of Life in Patients with Peripheral Arterial Disease: a systematic review.
决定周围动脉疾病患者的生活质量:系统评价。
  • DOI:
  • 发表时间:
    2019
  • 期刊:
  • 影响因子:
    0
  • 作者:
    A. Aber;E. Lumley;Patrick Phillips;H. Woods;Georgina L Jones;J. Michaels
  • 通讯作者:
    J. Michaels
A systematic review to identify anxiety measures for use in populations undergoing abdominal aortic aneurysm screening.
一项系统评价,以确定用于接受腹主动脉瘤筛查的人群的焦虑措施。
  • DOI:
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    1
  • 作者:
    Patrick Phillips;Gill Rooney;E. Wilson;J. Michaels
  • 通讯作者:
    J. Michaels
Applying Neuro-Informed Career-Focused Counselling: A Single Case Study Analysis
应用神经知情职业咨询:单个案例研究分析

Patrick Phillips的其他文献

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{{ truncateString('Patrick Phillips', 18)}}的其他基金

DISSERTATION RESEARCH: Interaction of gene flow, selection and genomic architecture on the genetics of adaptation
论文研究:基因流、选择和基因组结构对适应遗传学的相互作用
  • 批准号:
    1601794
  • 财政年份:
    2016
  • 资助金额:
    $ 466.61万
  • 项目类别:
    Standard Grant
Two-month Regimens Using Novel Combinations to Augment Treatment Effectiveness for drug-sensitive Tuberculosis: the "TRUNCATE-TB" trial
使用新组合的两个月治疗方案来增强药物敏感结核病的治疗效果:“TRUNCATE-TB”试验
  • 批准号:
    MR/L004356/1
  • 财政年份:
    2014
  • 资助金额:
    $ 466.61万
  • 项目类别:
    Research Grant
Mating systems and the origins of genetic conflict
交配系统和遗传冲突的起源
  • 批准号:
    1120417
  • 财政年份:
    2011
  • 资助金额:
    $ 466.61万
  • 项目类别:
    Continuing Grant
DISSERTATION RESEARCH: Determining the functional genetic basis of natural variation in thermosensory behavior
论文研究:确定热感觉行为自然变异的功能遗传基础
  • 批准号:
    0909816
  • 财政年份:
    2009
  • 资助金额:
    $ 466.61万
  • 项目类别:
    Standard Grant
DISSERTATION RESEARCH: Outcrossing in a Self-Fertilizing Species, Adding the Caenorhabditis elegans Tool-Kit to the Outcrossing-Selfing Paradigm
论文研究:自体受精物种中的异型杂交,将秀丽隐杆线虫工具包添加到异型杂交自交范式中
  • 批准号:
    0710386
  • 财政年份:
    2007
  • 资助金额:
    $ 466.61万
  • 项目类别:
    Standard Grant
Partial Selfing and the Genetic Basis of Mating System Variation
部分自交和交配系统变异的遗传基础
  • 批准号:
    0641066
  • 财政年份:
    2007
  • 资助金额:
    $ 466.61万
  • 项目类别:
    Continuing Grant
DISSERTATION RESEARCH: Evolution of neuronal regulatory genes in Caenorhabditis
论文研究:秀丽隐杆线虫神经元调节基因的进化
  • 批准号:
    0710378
  • 财政年份:
    2007
  • 资助金额:
    $ 466.61万
  • 项目类别:
    Standard Grant
OPUS: Evolution of Genetic Architecture
OPUS:遗传结构的进化
  • 批准号:
    0614588
  • 财政年份:
    2006
  • 资助金额:
    $ 466.61万
  • 项目类别:
    Standard Grant
DISSERTATION RESEARCH: Direct Tests of the Adaptive Benefits of Gene Exchange in Evolving Bacterial Populations
论文研究:基因交换对进化细菌种群的适应性益处的直接测试
  • 批准号:
    0508919
  • 财政年份:
    2005
  • 资助金额:
    $ 466.61万
  • 项目类别:
    Standard Grant
Collaborative Research: Experimental Tests of the Adaptive Significance of Ectotherm Thermoregulation
合作研究:变温体温调节适应性意义的实验测试
  • 批准号:
    0416205
  • 财政年份:
    2004
  • 资助金额:
    $ 466.61万
  • 项目类别:
    Continuing Grant

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